Table 2 Quantifiable metrics of acute exacerbations in CRS
Author/year | Evaluation parameters of AE | Results | Conclusions | Level of evidence |
|---|---|---|---|---|
Phillips, et al. (2017) [6] | Number of CRS-related antibiotics usage, sinus infections | SNOT-22 score is associated with the number of antibiotics; Antibiotic usage highly correlated with the number of reported sinus infections. | Sinusitis-related antibiotic usage, reflecting the frequency of acute CRS exacerbations, mediates the association between CRS symptomatology and QOL. | 3a |
Banoub, et al. (2018) [11] | Number of sinus infections, CRS-related antibiotics use, CRS-related oral corticosteroids use | The frequency of patient-reported sinus infections, CRS-related antibiotics courses and CRS-related oral corticosteroid courses was negatively associated with asthma control. | AE are negatively associated with the level of asthma control. | 3a |
Phillips, et al. (2019) [18] | Number of sinus infections, CRS-related antibiotics, CRS-related oral corticosteroids | AE positively associated with comorbid asthma, and SNOT-22. | A CRS exacerbation-prone phenotype characterized by high sinonasal disease burden with comorbid asthma. | 3a |
Sedaghat, et al. (2018) [19] | Number of sinus infections, CRS-related oral antibiotic, CRS-related oral corticosteroids | At least 1 course of antibiotics or oral corticosteroids in the last 3 months was the optimal threshold for detecting poorly controlled CRS. | Number of CRS-related antibiotic use, and CRS-related oral corticosteroid aid in the determination of global CRS control. | 3a |
Speth, et al. (2018) [20] | Number of sinus infections, CRS-related antibiotics, CRS-related steroid usage | SNOT-22 score ≥ 30 predicted at least 1 sinus infection, CRS-related antibiotics, or CRS-related oral corticosteroids in the past 3 months. | SNOT-22 score and AE were predictive of each other. | 3a |
Zemke, et al. (2019) [13] | SNOT-22 scores | SNOT-22 scores were 4.9 points higher during the AE | Changes of SNOT-22 indicate the AE. | 3a |
Diveka, et al. (2015) [14] | SNOT-22 scores | SNOT-22 scores were 10.75 higher during the AE | Changes of SNOT-22 indicate the AE. | 3a |