Table 4 Demographic and clinical characteristics of the study population (n = 65,881)

Age

61.0 ± 12.7

42.9 ± 13.6

 < 0.001

46.3 ± 13.2

46.4 ± 12.4

0.5

Sex

 Male

33,253 (55.8%)

4814 (57.8%)

0.001

3901 (58.7%)

3849 (57.9%)

0.4

 Female

26,285 (44.1%)

3508 (42.1%)

0.001

2750 (41.3%)

2801 (42.1%)

0.4

 Unknown

31 (0.1%)

10 (0.1%)

0.02

0

10 (0.2%)

0.002

Race

 White

41,427 (69.5%)

5247 (63.0%)

 < 0.001

4247 (63.9%)

4246 (63.8%)

1.0

 Black or African American

8322 (14.0%)

1362 (16.4%)

 < 0.001

1014 (15.2%)

1034 (15.5%)

0.6

 Asian

353 (0.6%)

141 (1.7%)

 < 0.001

89 (1.3%)

96 (1.4%)

0.6

 American Indian or Alaska Native

244 (0.4%)

35 (0.4%)

1.0

33 (0.5%)

32 (0.5%)

0.9

 Native Hawaiian or Other Pacific Islander

52 (0.1%)

12 (0.1%)

0.1

10 (0.2%)

10 (0.2%)

1

 Unknown

9171 (15.4%)

1526 (18.3%)

 < 0.001

1261 (19.0%)

1233 (18.5%)

0.5

Ethnicity

 Not Hispanic or  Latino

46,411 (77.9%)

5490 (66.0%)

 < 0.001

4560 (68.6%)

4577 (68.8%)

0.8

 Hispanic or Latino

2399 (4.0%)

773 (9.3%)

 < 0.001

507 (7.6%)

519 (7.8%)

0.7

 Unknown

10,759 (18.1%)

2060 (24.8%)

 < 0.001

1584 (23.8%)

1555 (23.4%)

0.6

Comorbidities

 Diabetes mellitus

29,077 (48.8%)

1255 (15.1%)

 < 0.001

1195 (18.0%)

1227 (18.4%)

0.5

 Tobacco use

3045 (5.1%)

190 (2.3%)

 < 0.001

160 (2.4%)

177 (2.7%)

0.3

 Overweight, obesity and other hyperalimentation

39,864 (66.9%)

3183 (38.2%)

 < 0.001

2927 (44.0%)

2885 (43.4%)

0.5

 Other chronic obstructive pulmonary disease

16,460 (27.6%)

429 (5.2%)

 < 0.001

405 (6.1%)

427 (6.4%)

0.4

 Diseases of the nervous system

54,858 (92.1%)

7280 (87.5%)

 < 0.001

5782 (86.9%)

5763 (86.6%)

0.6

 Cerebrovascular diseases

11,177 (18.8%)

344 (4.1%)

 < 0.001

351 (5.3%)

329 (4.9%)

0.4

 Other forms of heart disease

36,447 (61.2%)

1636 (19.7%)

 < 0.001

1588 (23.9%)

1555 (23.4%)

0.5

 Ischemic heart diseases

23,472 (39.4%)

645 (7.7%)

 < 0.001

665 (10.0%)

635 (9.5%)

0.4

 Other and unspecified disorders of the circulatory system

12,741 (21.4%)

456 (5.5%)

 < 0.001

415 (6.2%)

416 (6.3%)

1.0

 Diseases of veins, lymphatic vessels and lymph nodes

15,401 (25.9%)

683 (8.2%)

 < 0.001

635 (9.5%)

631 (9.5%)

0.9

 Diseases of arteries, arterioles and capillaries

15,873 (26.6%)

519 (6.2%)

 < 0.001

544 (8.2%)

497 (7.5%)

0.1

 Pulmonary heart disease and diseases of pulmonary circulation

13,086 (22.0%)

221 (2.7%)

 < 0.001

252 (3.8%)

217 (3.3%)

0.1

 Chronic rheumatic heart diseases

6295 (10.6%)

102 (1.2%)

 < 0.001

103 (1.5%)

100 (1.5%)

0.8

 Acute rheumatic fever

218 (0.4%)

10 (0.1%)

 < 0.001

10 (0.2%)

10 (0.2%)

1

 Hypertensive diseases

47,055 (79.0%)

3130 (37.6%)

 < 0.001

2996 (45.0%)

2984 (44.9%)

0.8

 Diseases of the digestive system

45,097 (75.7%)

4965 (59.7%)

 < 0.001

4179 (62.8%)

4151 (62.4%)

0.6

 Mental, Behavioral and Neurodevelopmental disorders

38,332 (64.3%)

4016 (48.3%)

 < 0.001

3461 (52.0%)

3435 (51.6%)

0.7

 Diseases of the genitourinary system

41,119 (69.0%)

3717 (44.7%)

 < 0.001

3098 (46.6%)

3144 (47.3%)

0.4

 Malignant neoplasms of eye, brain and other parts of CNS

235 (0.4%)

21 (0.3%)

0.05

21 (0.3%)

18 (0.3%)

0.6

 Epilepsy and recurrent seizures

2661 (4.5%)

258 (3.1%)

 < 0.001

239 (3.6%)

225 (3.4%)

0.5