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Table 1 Reported cases of squamous cell carcinoma implantation at a PEG tube site

From: Percutaneous endoscopic gastrostomy site metastasis from head and neck squamous cell carcinoma: case series and literature review

Author Age Sex Site of primary disease TNM stage Treatment of primary disease Timing of PEG placement (before or after primary therapy) Time from PEG placement to stomal metastasis (months) Other concurrent treatment failure sites Treatment of PEG-site metastasis Length of survival after PEG metastasis diagnosis (months)
Adelson[17] 63 M Oropharynx NA Surgery Before 6 Lung, liver Chemo 4
Ananth[3] 55 M Oral Cavity T1N2aM0 Surgery + XRT Before 3.5 NCR Surgery + Chemo NED
Balakrishnan[18] 50 M Larynx NA Surgery Before NA NCR Surgery NA
Becker[19] 49 M Hypopharynx T4N3M0 XRT Before 3 Lung Surgery 5
Bhama[20] 51 M Hypopharynx T2N1M0 XRT Before 3.5 Liver, pelvis Surgery 4
Bushnell[9] 68 M Supraglottis T4N2bM0 Surgery + XRT After 14 Lung None 18
Chatni[10] 53 F Hypopharynx NA XRT After 5 Neck None NA
Coletti[21] 65 M Oral Cavity T4N2cM0 ChemoXRT Before 9 NCR ChemoXRT 2
Cossentino[22] 62 M Oropharynx T4N2M0 Surgery + XRT Before 8 Lung None 2
  66 M Oropharynx T3N1M0 XRT Before 9 NA None NA
Cruz[23] 58 M Oral Cavity T4N0M0 XRT Before 5 NA Surgery + Chemo 4
  48 M Hypopharynx T4N3M0 Surgery + ChemoXRT Before 6 NA Surgery 4
Daniels[24] 56 M Oral Cavity TxN+M0 Surgery + XRT Before 3 NA Chemo + Surgery NA
Douglas[15] 45 M Oropharynx T4N3M0 XRT Before 3.5 NCR XRT 9
Hawkin[8] 68 M Oropharynx T3N0M0 XRT Before 14 NCR None 1
Huang[25] 53 M Oropharynx T4N2aM0 Surgery + XRT Before 6 NA NA NA
Kurdow[26] 75 F Hypopharynx T4N0M0 XRT Before 4 NA NA NA
Laccourreye[11] 65 M Hypopharynx T3N0M0 ChemoXRT After 11 Liver XRT 4
Lee[27] 41 M Oropharynx T4N2bM0 Surgery + ChemoXRT Before 13 Liver, spleen None 1
Lim[28] 51 M Oropharynx T4N1M0 Surgery + XRT Before 8 Lung Surgery NA
Lin[13] 56 M Oropharynx T4N0M0 Surgery + XRT Before 5 NCR NA 2
Maccabee[29] 63 F Hypopharynx T4N1M0 ChemoXRT Before 5 Primary site None 3
Meurer[30] 45 M Oropharynx T3N1M0 Surgery Before 12 Lung ChemoXRT 17
  76 F Oropharynx T2N0M0 XRT Before 13 Lung Surgery 16
Mincheff[4] 59 M Oropharynx T4N2bM0 Surgery + XRT NA 4 NCR Surgery + XRT NA (Hospice)
Potochny[31] 44 M Hypopharynx T2N2M0 Surgery + XRT Before 9 NCR Surgery NED
Preyer[14] 72 M Oropharynx T4N2cM0 ChemoXRT Before 3 Lung None 3
Purandare[32] 50 F Oropharynx T3N2M0 Surgery NA 9 Primary site, neck NA NA
  62 M Oral Cavity T2N0M0 Surgery NA 15 Primary site NA NA
Schiano[12] 43 M Hypopharynx T4NxM0 Chemo After 4 Primary site, neck NA NA
Schneider[33] 61 F Oropharynx T4N0M0 Surgery + XRT Before 10 NCR Surgery NED
Sharma[34] 40 M Oral Cavity T4N3M0 ChemoXRT Before 6 Primary site Surgery + Chemo NA (Hospice)
Siddiqi[35] 56 F Supraglottis T3N2bM0 ChemoXRT Before 7 NA NA 2
Sinclair[36] 61 M Oropharynx T2N1M0 XRT Before 5 Left axilla Surgery + ChemoXRT NA (recurrent disease detected)
Thakore[37] 50 M Larynx NA Surgery + ChemoXRT NA NA Lung, hip, brain ChemoXRT 6
Thorburn[38] 56 M Supraglottis T4N3M0 XRT Before 11 NA NA 1
Tucker[16] NA NA Hypopharynx NA ChemoXRT Before 3 NA NA NA
Van erpecum[39] 69 M Hypopharynx T4N0M0 XRT Before 10 NCR XRT + Surgery 1
Current series 69 M Hypopharynx T2N2aM0 ChemoXRT Before 22 Adrenals, liver, lung Chemo XRT 8
  77 M Supraglottis T3N1M0 ChemoXRT Before 16 NCR Chemo 5
  46 M Oral Cavity T4N1M0 ChemoXRT Before 8 NCR Surgery 19
  64 M Oropharynx T1N2cM0 XRT Before 7 Primary site, neck Surgery NED
Total cases 42          
  1. Abbreviations: NA, not available; Chemo, Chemotherapy; XRT, radiation therapy; NCR, no concurrent recurrence; NED, no evidence of disease.