Cyclin D1 overexpression is associated with poor prognosis in oropharyngeal cancer

Table 2 Comparison of patient characteristics between two outcome groups

	Total (N = 60)	Group 1^a(N=39, 65%)	Group 2^a(N = 21, 35%)	P value
Mean age at diagnosis (yr ± SD)	60.4 ± 11.7	59.8 ± 11.3	61.4 ± 12.6	0.63
Gender
Male	46 (77)	30 (77)	16 (76)
Female	14 (23)	9 (23)	5 (24)	1
Smoking Habit
Non-smokers	14 (23)	10 (26)	4 (19)	0.78
Former smokers (quit > 5 yr)	15 (25)	9 (23)	6 (29)
Current smokers	29 (48)	20 (51)	9 (43)
Unknown^e	2 (3)	0 (0)	2 (10)
Alcohol ^b
Never or light	51 (85)	34 (87)	17 (81)	1
Heavy	7 (12)	5 (13)	2 (10)
Unknown^e	2 (3)	0 (0)	2 (10)
T staging
1	25 (42)	19 (49)	6 (29)	0.44
2	15 (25)	9 (23)	6 (29)
3	12 (20)	6 (15)	6 (29)
4	3 (5)	2 (5)	1 (5)
Unknown^e	5 (8)	3 (8)	2 (10)
N staging
N0	7 (12)	6 (15)	1 (5)	0.4
N+	51 (85)	32 (82)	19 (90)
Unknown^e	2 (3)	1 (3)	1 (5)
TNM staging ^c
1	2 (3)	2 (5)	0 (0)	0.61
2	4 (7)	3 (8)	1 (5)
3	11 (18)	6 (15)	5 (24)
4	41 (68)	27 (69)	14 (67)
Unknown^e	2 (3)	1 (3)	1 (5)
Treatment information
Surgery (S/T) only	3 (5)	2 (5)	1 (5)	0.12
Radiation (XRT) only^d	30 (50)	18 (46)	12 (57)
Chemotherapy only	11 (18)	5 (13)	6 (29)
Combined S/T and XRT	16 (27)	14 (36)	2 (10)
Mean Follow-Up Time (yr ± SD)	4 ± 2.4	4.7 ± 2.2	2 ± 1.6	< 0.0001

^aOutcome: Group 1, those survived with no disease or died due to other cause (disease-free survival); Group 2, those alive with disease or died of disease (progress-free survival or disease-specific deaths).
^bHeavy alcohol intake was defined as > 3 drinks/day for males and > 2 drinks/day for females.
^cTNM staging is based on the American Joint Committee on Cancer (AJCC) Cancer Staging Manual. 7th ed 2010.
^dRadiation only include radiation only with/without induction chemotherapy.
^eMissing values (Group 1 (N): Group 2 (N)): Smoking Habit (0:2), Alcohol (0:2), T-staging (3:2); Nodal Status (1:1); TNM staging (1:1).

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