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Table 1 Characteristics of patients and tumors by treatment group

From: Survival outcomes of patients with advanced oral cavity squamous cell carcinoma treated with multimodal therapy: a multi-institutional analysis

  Group  
Variable S-CRT S-RT CRT RT p-Value
n 43 140 10 28 -
Age      
Mean, yrs 53.5 61.9 61.1 77.4 <0.001*
Range, yrs 16.3 – 78.0 35.5 – 93.6 45.2 – 74.5 53.1 – 95.0  
Gender, no. (%)      0.01*
Male 21 (48.8) 95 (67.9) 6 (60.0) 11 (39.3)  
Female 22 (51.2) 45 (32.1) 4 (40.0) 17 (60.7)  
Charlston Comorbidity Index, mean score (range) 1.9 (0–9) 2.3 (0–7) 3.0 (0–7) 5.4 (0–9) <0.001*
Site of tumor, no. (%)      
Tongue, 23 (53.5) 51 (36.4) 6 (60) 8 (28.6) 0.92
Floor of Mouth 8 (18.6) 37 (26.4) 2 (20.0) 7 (25.0)  
Other 12 (27.9) 52 (37.1) 2 (20) 13 (46.4)  
cT-stage, no. (%)      0.16
1 1 (2.3) 9 (6.4) 1 (10.0) 0 (0.0)  
2 15 (34.9) 39 (27.9) 2 (20.0 5 (17.8)  
3 13 (30.2) 28 (20.0) 1 (10.0) 4 (14.2)  
4 14 (32.6) 64 (45.7) 6 (60.0) 19 (67.8)  
cN-stage, no. (%)      <0.001*
N0 2 (4.7) 39 (27.9) 2 (20.0) 12 (42.9)  
N1 4 (9.3) 52 (37.1) 3 (30.0) 11 (39.3)  
N2a 3 (7.0) 23 (16.4) 2 (20.0) 2 (7.1)  
N2b 18 (41.9) 15 (10.7) 2 (20.0) 2 (7.1)  
N2c 14 (32.6) 7 (5.0) 0 (0.0) 1 (3.6)  
N3 2 (4.7) 4 (2.9) 1 (10.0) 0 (0.0)  
Perineural Invasion, no. (%) 21 (48.8) 34 (24.3) / / 0.004*
Lymph-vascular Invasion, no. (%) 31 (72.1) 24 (17.1) / / <0.001*
Extracapsular spread, no. (%) 27 (62.8) 46 (32.9) / / 0.001*
Overall stage, no. (%)      0.60
III 4 (9.3) 46 (32.9) 0 (0) 7 (25)  
IV 39 (90.7) 94 (67.2) 10 (100) 21 (75)  
Death, no. (%) 17 (39.5) 89 (63.6) 10 (100) 26 (92.9)  
Death, cause (%)      0.37
Primary Cancer 47.1 85.4 90 92.3
Other Cancer 23.5 5.6 0 3.8
Non-Cancer 29.4 10.1 10 11.5
  1. Abbreviations: S-CRT, Surgery with adjuvant chemo-radiation therapy; S-RT, Surgery with adjuvant radiation therapy; CRT, Primary chemo-radiation therapy; RT, Primary radiation therapy; no., Number; yrs, Years; cT-stage, Clinical T-stage; cN-stage, Clinical N-stage.
  2. * There were no statistically significant differences between the two treatment groups of S-CRT and S-RT.