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Table 1 Characteristics of patients and tumors by treatment group

From: Survival outcomes of patients with advanced oral cavity squamous cell carcinoma treated with multimodal therapy: a multi-institutional analysis

 

Group

 

Variable

S-CRT

S-RT

CRT

RT

p-Value

n

43

140

10

28

-

Age

     

Mean, yrs

53.5

61.9

61.1

77.4

<0.001*

Range, yrs

16.3 – 78.0

35.5 – 93.6

45.2 – 74.5

53.1 – 95.0

 

Gender, no. (%)

    

0.01*

Male

21 (48.8)

95 (67.9)

6 (60.0)

11 (39.3)

 

Female

22 (51.2)

45 (32.1)

4 (40.0)

17 (60.7)

 

Charlston Comorbidity Index, mean score (range)

1.9 (0–9)

2.3 (0–7)

3.0 (0–7)

5.4 (0–9)

<0.001*

Site of tumor, no. (%)

     

Tongue,

23 (53.5)

51 (36.4)

6 (60)

8 (28.6)

0.92

Floor of Mouth

8 (18.6)

37 (26.4)

2 (20.0)

7 (25.0)

 

Other

12 (27.9)

52 (37.1)

2 (20)

13 (46.4)

 

cT-stage, no. (%)

    

0.16

1

1 (2.3)

9 (6.4)

1 (10.0)

0 (0.0)

 

2

15 (34.9)

39 (27.9)

2 (20.0

5 (17.8)

 

3

13 (30.2)

28 (20.0)

1 (10.0)

4 (14.2)

 

4

14 (32.6)

64 (45.7)

6 (60.0)

19 (67.8)

 

cN-stage, no. (%)

    

<0.001*

N0

2 (4.7)

39 (27.9)

2 (20.0)

12 (42.9)

 

N1

4 (9.3)

52 (37.1)

3 (30.0)

11 (39.3)

 

N2a

3 (7.0)

23 (16.4)

2 (20.0)

2 (7.1)

 

N2b

18 (41.9)

15 (10.7)

2 (20.0)

2 (7.1)

 

N2c

14 (32.6)

7 (5.0)

0 (0.0)

1 (3.6)

 

N3

2 (4.7)

4 (2.9)

1 (10.0)

0 (0.0)

 

Perineural Invasion, no. (%)

21 (48.8)

34 (24.3)

/

/

0.004*

Lymph-vascular Invasion, no. (%)

31 (72.1)

24 (17.1)

/

/

<0.001*

Extracapsular spread, no. (%)

27 (62.8)

46 (32.9)

/

/

0.001*

Overall stage, no. (%)

    

0.60

III

4 (9.3)

46 (32.9)

0 (0)

7 (25)

 

IV

39 (90.7)

94 (67.2)

10 (100)

21 (75)

 

Death, no. (%)

17 (39.5)

89 (63.6)

10 (100)

26 (92.9)

 

Death, cause (%)

    

0.37

Primary Cancer

47.1

85.4

90

92.3

Other Cancer

23.5

5.6

0

3.8

Non-Cancer

29.4

10.1

10

11.5

  1. Abbreviations: S-CRT, Surgery with adjuvant chemo-radiation therapy; S-RT, Surgery with adjuvant radiation therapy; CRT, Primary chemo-radiation therapy; RT, Primary radiation therapy; no., Number; yrs, Years; cT-stage, Clinical T-stage; cN-stage, Clinical N-stage.
  2. * There were no statistically significant differences between the two treatment groups of S-CRT and S-RT.