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Table 2 The inclusion, exclusion criteria and definition of FDG-PET positivity of these 7 studies

From: Is fluorine-18 fluorodeoxyglucose positron emission tomography useful for the thyroid nodules with indeterminate fine needle aspiration biopsy? a meta-analysis of the literature

Study

Year

Inclusion criteria

Exclusion criteria

Definition of FDG-PET positivity

Kresnik [10]

2003

All patients with TN; hypoechogenic or no uptake on scintigraphy; follicular or Hürthle cell proliferation on FNAB; scheduled for surgery

Autonomous goiter

Focal uptake with SUV > 2

de Geus-Oei [11]

2006

Palpable TN; FNAB: a follicular neoplasm or a Hürthle cell (oncocytic) neoplasm, if they showed atypical papillary cells, or if the sample was repeatedly insufficient; scheduled for hemithyroidectomy

DM; pregnancy

Focal uptake

Sebastianes [12]

2007

FNAB: hypercellular follicular and oxyphilic nodules suggestive of follicular neoplasm and also includes lesions that are suspect but not diagnostic of papillary carcinoma; scheduled for hemithyroidectomy

Uncontrollable DM; other malignancies; pregnancy; abnormal TSH

Focal uptake

Hales [13]

2008

All patients with TN; either follicular or Hürthle cell lesion by FNAB

Pregnancy; breastfeeding; previous neck surgery; >181 kg bodyweight

Focal uptake with SUV >2

Smith [14]

2008

Patients with a preoperative diagnosis of follicular neoplasm by FNAB for whom surgical excision was planned

None

Area under SUV curve > 175.5

Traugott [15]

2010

Adults with TN or dominant TN; palpable or >1 cm on Utrasound; scheduled for surgery; FNAB: follicular lesion, Hürthle cell or oncocytic cell lesion, atypical cytology, abnormal cytology, or suspicious cytology

Previous neck surgery; previous radiotherapy

Focal uptake

Deandreis [16]

2012

Patient age > 18 years; TN with a diameter ≥ 1cm; FNAB: indeterminate follicular lesions

DM; abnormal TSH

Focal uptake

  1. TN: thyroid nodule, DM: diabetes mellitus.