Study | Year | Inclusion criteria | Exclusion criteria | Definition of FDG-PET positivity |
---|---|---|---|---|
Kresnik [10] | 2003 | All patients with TN; hypoechogenic or no uptake on scintigraphy; follicular or Hürthle cell proliferation on FNAB; scheduled for surgery | Autonomous goiter | Focal uptake with SUV > 2 |
de Geus-Oei [11] | 2006 | Palpable TN; FNAB: a follicular neoplasm or a Hürthle cell (oncocytic) neoplasm, if they showed atypical papillary cells, or if the sample was repeatedly insufficient; scheduled for hemithyroidectomy | DM; pregnancy | Focal uptake |
Sebastianes [12] | 2007 | FNAB: hypercellular follicular and oxyphilic nodules suggestive of follicular neoplasm and also includes lesions that are suspect but not diagnostic of papillary carcinoma; scheduled for hemithyroidectomy | Uncontrollable DM; other malignancies; pregnancy; abnormal TSH | Focal uptake |
Hales [13] | 2008 | All patients with TN; either follicular or Hürthle cell lesion by FNAB | Pregnancy; breastfeeding; previous neck surgery; >181 kg bodyweight | Focal uptake with SUV >2 |
Smith [14] | 2008 | Patients with a preoperative diagnosis of follicular neoplasm by FNAB for whom surgical excision was planned | None | Area under SUV curve > 175.5 |
Traugott [15] | 2010 | Adults with TN or dominant TN; palpable or >1 cm on Utrasound; scheduled for surgery; FNAB: follicular lesion, Hürthle cell or oncocytic cell lesion, atypical cytology, abnormal cytology, or suspicious cytology | Previous neck surgery; previous radiotherapy | Focal uptake |
Deandreis [16] | 2012 | Patient age > 18 years; TN with a diameter ≥ 1cm; FNAB: indeterminate follicular lesions | DM; abnormal TSH | Focal uptake |