|  |  | All high-risk HPV | HPV-16 only | ||||
---|---|---|---|---|---|---|---|---|
Patient characteristic | Total | Negative | Positive | p* | Negative | Positive | p* | |
Age | <60 | 51 | 16 | 35 | <0.001 | 18 | 33 | <0.001 |
> = 60 | 44 | 29 | 15 |  | 32 | 12 |  | |
Gender | Male | 75 | 32 | 43 | 0.08 | 37 | 38 | 0.32 |
Female | 20 | 13 | 7 | Â | 13 | 7 | Â | |
Subsite | Tonsil | Â | 21 | 31 | 0.02 | 23 | 29 | 0.01 |
Base of Tongue | Â | 10 | 15 | Â | 12 | 13 | Â | |
Other | Â | 14 | 4 | Â | 15 | 3 | Â | |
T Classification | 1 | 14 | 4 | 10 | 0.27 | 4 | 10 | 0.19 |
2 | 25 | 11 | 14 | Â | 14 | 11 | Â | |
3 | 30 | 18 | 12 | Â | 19 | 11 | Â | |
4 | 26 | 12 | 14 | Â | 13 | 13 | Â | |
N Classification | 0 | 18 | 13 | 5 | 0.09 | 16 | 2 | 0.002 |
1 | 13 | 7 | 6 | Â | 8 | 5 | Â | |
2 | 54 | 21 | 33 | Â | 22 | 32 | Â | |
3 | 10 | 4 | 6 | Â | 4 | 6 | Â | |
Overal Stage | 1 | 2 | 1 | 1 | 0.49 | 1 | 1 | 0.02 |
2 | 9 | 5 | 4 | Â | 8 | 1 | Â | |
3 | 13 | 8 | 5 | Â | 10 | 4 | Â | |
4 | 71 | 31 | 40 | Â | 31 | 39 | Â | |
Smoking | never smokers | 20 | 4 | 16 | 0.006 | 5 | 1 | 0.001 |
1-9 py | 6 | 2 | 4 | Â | 2 | 4 | Â | |
10-19 py | 6 | 1 | 5 | Â | 1 | 5 | Â | |
>20 py | 57 | 35 | 22 | Â | 39 | 18 | Â | |
Unknown | 6 | 3 | 3 | Â | 3 | 3 | Â | |
Alcohol | < 21 drinks | 70 | 30 | 40 | 0.37 | 34 | 36 | 0.45 |
(drinks/wk) | >21 drinks | 17 | 10 | 7 | Â | 11 | 6 | Â |
Unknown | 8 | 5 | 3 | Â | 5 | 3 | Â | |
Treatment | CRT | 62 | 29 | 33 | 0.78 | 30 | 32 | 0.55 |
Radiation | 11 | 5 | 6 | Â | 8 | 3 | Â | |
Induction + CRT | 13 | 5 | 8 |  | 6 | 7 |  | |
Surgery + CRT | 5 | 3 | 2 |  | 3 | 2 |  | |
Surgery + RT | 2 | 1 | 1 |  | 1 | 1 |  | |
Surgery | 2 | 2 | 0 | Â | 2 | 0 | Â | |
HPV Type | 16 | 45 | 0 | 45 | Â | 0 | 45 | Â |
18 | 2 | 0 | 2 | Â | 2 | 0 | Â | |
33 | 1 | 0 | 1 | Â | 1 | 0 | Â | |
67 | 2 | 0 | 2 | Â | 2 | 0 | Â | |
p16 | Negative | 35 | 34 | 1 | <0.001 | 34 | 1 | <0.001 |
Positive | 59 | 10 | 49 | Â | 15 | 44 | Â |