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Table 2 Correlation of HPV status with patient and tumor factors

From: Does HPV type affect outcome in oropharyngeal cancer?

   

All high-risk HPV

HPV-16 only

Patient characteristic

Total

Negative

Positive

p*

Negative

Positive

p*

Age

<60

51

16

35

<0.001

18

33

<0.001

> = 60

44

29

15

 

32

12

 

Gender

Male

75

32

43

0.08

37

38

0.32

Female

20

13

7

 

13

7

 

Subsite

Tonsil

 

21

31

0.02

23

29

0.01

Base of Tongue

 

10

15

 

12

13

 

Other

 

14

4

 

15

3

 

T Classification

1

14

4

10

0.27

4

10

0.19

2

25

11

14

 

14

11

 

3

30

18

12

 

19

11

 

4

26

12

14

 

13

13

 

N Classification

0

18

13

5

0.09

16

2

0.002

1

13

7

6

 

8

5

 

2

54

21

33

 

22

32

 

3

10

4

6

 

4

6

 

Overal Stage

1

2

1

1

0.49

1

1

0.02

2

9

5

4

 

8

1

 

3

13

8

5

 

10

4

 

4

71

31

40

 

31

39

 

Smoking

never smokers

20

4

16

0.006

5

1

0.001

1-9 py

6

2

4

 

2

4

 

10-19 py

6

1

5

 

1

5

 

>20 py

57

35

22

 

39

18

 

Unknown

6

3

3

 

3

3

 

Alcohol

< 21 drinks

70

30

40

0.37

34

36

0.45

(drinks/wk)

>21 drinks

17

10

7

 

11

6

 

Unknown

8

5

3

 

5

3

 

Treatment

CRT

62

29

33

0.78

30

32

0.55

Radiation

11

5

6

 

8

3

 

Induction + CRT

13

5

8

 

6

7

 

Surgery + CRT

5

3

2

 

3

2

 

Surgery + RT

2

1

1

 

1

1

 

Surgery

2

2

0

 

2

0

 

HPV Type

16

45

0

45

 

0

45

 

18

2

0

2

 

2

0

 

33

1

0

1

 

1

0

 

67

2

0

2

 

2

0

 

p16

Negative

35

34

1

<0.001

34

1

<0.001

Positive

59

10

49

 

15

44

 
  1. HPV human papillomavirus, py pack years, RT radiation, CRT chemoradiation.
  2. * Fisher exact test.