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Table 4 Univariate and multivariate relations to disease free survival

From: Does HPV type affect outcome in oropharyngeal cancer?

   DFS (Univariate analysis) DFS (Multivariate analysis)
   HR (95% CI)* P** HR (95% CI)* P**
Age > = 60 vs <60 3.34 (1.44-7.71) 0.01   
Sex Male vs Female 1.06 (0.40-2.81) 0.91   
Site Tonsil, BOT vs Other     
T stage 3,4 vs 1,2 1.00 (0.46-2.17) 0.99   
N stage N + vs N0 0.51 (0.22-1.18) 0.11   
Smoking >10 py vs < 10 py or unknown 1.54 (0.64-3.72) 0.34   
Alcohol >21 drinks vs <21 drinks and Unknown 0.94 (0.33-2.75) 0.92   
p16 Positive vs Negative 0.41 (0.19-0.90) 0.025   
All High-Risk HPV Positive vs Negative 0.25 (0.11-0.58) 0.001 0.24 (0.10-0.56) 0.001
HPV 16 only Positive vs Negative 0.27 (0.11-0.65) 0.003   
   OS (Univariate Analysis) OS (Multivariate Analysis)
   HR (95% CI)* P** HR (95% CI)* P**
Age > = 60 vs <60 3.05 (1.06-8.80) 0.04   
Sex Male vs Female 0.70 (0.23-2.17) 0.53   
Site Tonsil, BOT vs Other 1.38 (0.39-4.90) 0.61   
T stage 3,4 vs 1,2 1.76 (0.61-5.07) 0.30   
N stage N + vs N0 0.37 (0.13-1.01) 0.05   
Smoking >10 py vs < 10 py or unknown 2.34 (0.67-8.25) 0.19   
Alcohol >21 drinks vs <21 drinks and Unknown 1.16 (0.33-4.09) 0.81   
p16 Positive vs Negative 0.24 (0.09-0.67) 0.006   
All High-Risk HPV Positive vs Negative 0.20 (0.06-0.62) 0.005 0.19 (0.06-0.60) 0.004
HPV 16 only Positive vs Negative 0.17 (0.05-0.59) 0.006   
  1. DFS disease-free survival, OS overal survival, HR hazard ratio, CI confidence interval, py pack years, HPV human papillomavirus.
  2. *CI (confidence interval) by Cox proportional hazard analysis.
  3. **Wald test.