Table 4 Univariate and multivariate relations to disease free survival

Age

> = 60 vs <60

3.34 (1.44-7.71)

0.01

Sex

Male vs Female

1.06 (0.40-2.81)

0.91

Site

Tonsil, BOT vs Other

T stage

3,4 vs 1,2

1.00 (0.46-2.17)

0.99

N stage

N + vs N0

0.51 (0.22-1.18)

0.11

Smoking

>10 py vs < 10 py or unknown

1.54 (0.64-3.72)

0.34

Alcohol

>21 drinks vs <21 drinks and Unknown

0.94 (0.33-2.75)

0.92

p16

Positive vs Negative

0.41 (0.19-0.90)

0.025

All High-Risk HPV

Positive vs Negative

0.25 (0.11-0.58)

0.001

0.24 (0.10-0.56)

0.001

HPV 16 only

Positive vs Negative

0.27 (0.11-0.65)

0.003

OS (Univariate Analysis)

OS (Multivariate Analysis)

HR (95% CI)*

P**

HR (95% CI)*

P**

Age

> = 60 vs <60

3.05 (1.06-8.80)

0.04

Sex

Male vs Female

0.70 (0.23-2.17)

0.53

Site

Tonsil, BOT vs Other

1.38 (0.39-4.90)

0.61

T stage

3,4 vs 1,2

1.76 (0.61-5.07)

0.30

N stage

N + vs N0

0.37 (0.13-1.01)

0.05

Smoking

>10 py vs < 10 py or unknown

2.34 (0.67-8.25)

0.19

Alcohol

>21 drinks vs <21 drinks and Unknown

1.16 (0.33-4.09)

0.81

p16

Positive vs Negative

0.24 (0.09-0.67)

0.006

All High-Risk HPV

Positive vs Negative

0.20 (0.06-0.62)

0.005

0.19 (0.06-0.60)

0.004

HPV 16 only

Positive vs Negative

0.17 (0.05-0.59)

0.006