Completion thyroidectomy: predicting bilateral disease

Table 6 Literature review of features predicting contralateral disease in well differentiated thyroid cancers

	Pasieka et al. 1992 [10] N = 60	Kawaura et al. 2001 [11] N = 128	Pacini et al. 2001 [12] N = 182	Alzahrani et al. 2002 [13] N = 101	Kim et al. 2004 [14] N = 81	Grigsby et al. 2006 [15] N = 150	Pitt et al. 2009 [16] N = 228^b
Malignancy on completion	53 %	56.3 %	44 %	51.5 %	36 %	41 %	29 %
Multifocality	88 % (n = 14/16)	76.6 % (n = 36/47)	NC	53.5 % (n = 15/28)	69 % (n = 20/29)	----	45 % (n = 9/20)
Multifocality	p < 0.001	p > 0.05	NC	p = 0.045	p < 0.001	----	p = 0.02
Size of Tumor	NC	NC	NC	NC	NC	NC	NC
Lymph node involvement	NC	76.5 % (n = 13/17)	73.3.% (n = 11/15)	----	NC	NC	NC
Lymph node involvement	NC	p > 0.05	p = 0.03	----	NC	NC	NC
Age	----	NC	NC	^a60.9 % (n = 14/23)	NC	NC	----
Age	----	NC	NC	p = 0.01	NC	NC	----
Gender	----	NC	NC	NC	----	NC	----
Thyroiditis	----	NC	----	----	----	----	----
Exposure to ionizing radiation	----	100 % (n = 6/6)	----	----	----	----	----
Exposure to ionizing radiation	----	p > 0.05	----	----	----	----	----
Low vs High Risk	----	----	NC	----	----	NC	----
Histopathologic Diagnosis	NC	----	NC	----	NC	----	----
Coexistent Benign Nodule	----	----	----	----	NC	----	NC
Extrathyroidal Extension	----	NC	----	^a61.5 % (n = 16/26)	NC	----	NC
Extrathyroidal Extension	----	NC	----	p = 0.01	NC	----	NC
Serum Tg > 20 ng/ml	----	----	----	56.7 % (n = 17/30)	----	----	----
Serum Tg > 20 ng/ml	----	----	----	p = 0.026	----	----	----
PC variant	----	NC (Tall cell)	----	----	----	NC (Follicular)	NC (Follicular)
Soft tissue invasion	----	----	----		----	NC	----
Vascular invasion	----	----	----		----	NC	NC
Resection margins	----	----	----		----	NC	NC
Tumor capsular invasion	----	----	----	----	----	----	NC

---- Feature not studied, NC No statistically significant correlation
^aPredictive of cervical lymph node metastasis only
^bPitt et al. [16]: the study of factors predicting contralateral disease is limited to PMC (<1 cm) n = 70

ISSN: 1916-0216