Table 1 Altered soft tissue protein abundances in cholesteatoma matrix relative to normal mucosa and post-auricular skin. Positive values indicate a greater abundance of a protein in cholesteatoma than the reference tissue. Italicized relative abundances indicate values below the detection threshold for one tissue but above detection threshold in the other. Study ID numbers correlate to Figs. 2 and 3
Protein name (study ID number) | NCBI gene ID | Number of unique peptides | Percent protein coverage (%) | Relative protein abundance | |
|---|---|---|---|---|---|
Mucosa | Skin | ||||
Bleomycin hydrolase (842) | BLMH | 4 | 13.8 | 7.66 | 1.14 |
Protein S100-A9 (92) | S100A9 | 5 | 55.3 | 4.66 | 3.83 |
Acyl-coenzyme A thioesterase 1 (1295) | ACOT1 | 2 | 5.7 | 4.62 | −1.26 |
Filaggrin (294) | FLG | 10 | 3.7 | 4.50 | 2.14 |
FA binding protein, epidermal (319) | FABP5 | 7 | 65.2 | 4.32 | 2.55 |
Filaggrin-2 (621) | FLG2 | 3 | 1.0 | 4.15 | 1.35 |
Protein S100-A7 (138) | S100A7 | 7 | 54.5 | 3.81 | 3.25 |
Creatine kinase B-type (944) | CKB | 2 | 7.9 | 3.74 | 1.47 |
Protein S100-A8 (162) | S100A8 | 5 | 64.5 | 3.50 | 3.80 |
Thymidine phosphorylase (150) | TYMP | 10 | 35.1 | 3.32 | 1.52 |
Serine protease inhibitor B3 (69) | SERPINB3 | 22 | 50.3 | 3.30 | 3.12 |
Myelin protein P0 (523) | MPZ | 6 | 25.0 | 2.92 | 1.06 |
Desmocollin-3 (989) | DSC3 | 3 | 4.2 | 2.07 | −3.42 |
Ferritin light chain (965) | FTL | 3 | 19.4 | 1.42 | 3.13 |
Fatty acid desaturase 2 (1301) | FADS2 | 2 | 3.6 | 1.32 | −5.34 |
Hydroxymethylglutaryl-CoA synthase, cytoplasmic (705) | HMGCS1 | 2 | 6.0 | 1.30 | −3.32 |
Fatty acid synthase (37) | FASN | 38 | 23.7 | 1.29 | −3.65 |
Collagen alpha-1(III) chain (754) | COL3A1 | 3 | 2.7 | 1.26 | −5.15 |
Collagen alpha-6(VI) chain (260) | COL6A6 | 10 | 7.0 | 1.18 | −3.95 |
Integrin alpha-M (909) | ITGAM | 4 | 3.9 | 1.16 | 3.28 |
Keratin, type II cytoskeletal 79 (359) | KRT79 | 15 | 27.7 | −1.03 | −5.48 |
Tenascin-X (111) | TNXB | 23 | 8.2 | −1.18 | −4.05 |
Serum amyloid P-component (269) | APCS | 5 | 23.3 | −1.23 | −3.27 |
Tryptase alpha/beta-1 (382) | TPSAB1 | 4 | 14.5 | −1.65 | −4.23 |
Collagen alpha-2(I) chain (151) | COL1A2 | 7 | 54.5 | −1.86 | −7.48 |
Mimecan/osteoglycin (126) | OGN | 7 | 24.8 | −1.89 | −5.49 |
Keratin type 2 cytoskeletal 8 (471) | KRT8 | 13 | 21.7 | −2.85 | −1.55 |
BPI fold containing family member B (865) | BPIFB1 | 3 | 8.5 | −3.06 | 1.68 |
Fibrillin-1 (70) | FBN1 | 27 | 11.3 | −3.08 | −1.23 |