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Table 1 Altered soft tissue protein abundances in cholesteatoma matrix relative to normal mucosa and post-auricular skin. Positive values indicate a greater abundance of a protein in cholesteatoma than the reference tissue. Italicized relative abundances indicate values below the detection threshold for one tissue but above detection threshold in the other. Study ID numbers correlate to Figs. 2 and 3

From: Identification of altered protein abundances in cholesteatoma matrix via mass spectrometry-based proteomic analysis

Protein name (study ID number) NCBI gene ID Number of unique peptides Percent protein coverage (%) Relative protein abundance
Mucosa Skin
Bleomycin hydrolase (842) BLMH 4 13.8 7.66 1.14
Protein S100-A9 (92) S100A9 5 55.3 4.66 3.83
Acyl-coenzyme A thioesterase 1 (1295) ACOT1 2 5.7 4.62 −1.26
Filaggrin (294) FLG 10 3.7 4.50 2.14
FA binding protein, epidermal (319) FABP5 7 65.2 4.32 2.55
Filaggrin-2 (621) FLG2 3 1.0 4.15 1.35
Protein S100-A7 (138) S100A7 7 54.5 3.81 3.25
Creatine kinase B-type (944) CKB 2 7.9 3.74 1.47
Protein S100-A8 (162) S100A8 5 64.5 3.50 3.80
Thymidine phosphorylase (150) TYMP 10 35.1 3.32 1.52
Serine protease inhibitor B3 (69) SERPINB3 22 50.3 3.30 3.12
Myelin protein P0 (523) MPZ 6 25.0 2.92 1.06
Desmocollin-3 (989) DSC3 3 4.2 2.07 −3.42
Ferritin light chain (965) FTL 3 19.4 1.42 3.13
Fatty acid desaturase 2 (1301) FADS2 2 3.6 1.32 −5.34
Hydroxymethylglutaryl-CoA synthase, cytoplasmic (705) HMGCS1 2 6.0 1.30 −3.32
Fatty acid synthase (37) FASN 38 23.7 1.29 −3.65
Collagen alpha-1(III) chain (754) COL3A1 3 2.7 1.26 −5.15
Collagen alpha-6(VI) chain (260) COL6A6 10 7.0 1.18 −3.95
Integrin alpha-M (909) ITGAM 4 3.9 1.16 3.28
Keratin, type II cytoskeletal 79 (359) KRT79 15 27.7 −1.03 −5.48
Tenascin-X (111) TNXB 23 8.2 −1.18 −4.05
Serum amyloid P-component (269) APCS 5 23.3 −1.23 −3.27
Tryptase alpha/beta-1 (382) TPSAB1 4 14.5 −1.65 −4.23
Collagen alpha-2(I) chain (151) COL1A2 7 54.5 −1.86 −7.48
Mimecan/osteoglycin (126) OGN 7 24.8 −1.89 −5.49
Keratin type 2 cytoskeletal 8 (471) KRT8 13 21.7 −2.85 −1.55
BPI fold containing family member B (865) BPIFB1 3 8.5 −3.06 1.68
Fibrillin-1 (70) FBN1 27 11.3 −3.08 −1.23