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Table 2 Altered abundances of proteins found in the cholesteatoma matrix proteome relative to healthy ossicles. Positive values indicate increased protein abundance in cholesteatoma. Study ID numbers correlate to Fig. 4

From: Identification of altered protein abundances in cholesteatoma matrix via mass spectrometry-based proteomic analysis

Protein name (study ID number) NCBI gene ID Number of unique peptides Percent protein coverage (%) Relative protein abundance
Normal ossicles
Isocitrate dehydrogenase 2 (199) IDH2 3 4.6 11.02
Creatine kinase B type (187) CKB 3 9.7 7.81
Thioredoxin domain-co8ntaining protein 5 (290) TXNDC5 3 12.0 6.76
Cytoskeleton-associated protein 4 (379) CKAP4 2 4.8 4.64
Protein disulfide-isomerase A6 (166) PDIA6 5 15.2 4.45
Ribosome binding protein 1 (251) RRBP1 3 2.4 4.19
Peptidyl-prolyl cis-trans isomerase (368) FKBP10 2 4.5 4.06
ATP synthase subunit α, mitochondrial (97) ATP5A1 9 21.2 3.92
Superoxide dismutase, mitochondrial (377) SOD2 2 17.2 3.92
60S ribosome L14 (298) RPL14 2 10.7 3.73
Stress-10 protein, mitochondrial (290) HSPA9 3 12.0 3.73
Guanine nucleotide binding protein subunit β-2 (283) GNB2L1 4 18.3 3.63
Malate dehydrogenase 2 (165) MDH2 6 25.4 3.62
Serine protease inhibitor H1 (248) SERPINH1 4 14.6 3.50
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase (284) DDOST 3 7.7 3.48
Elongation factor Tu (253) TUFM 3 10.6 3.45
ATP synthase subunit β, mitochondrial (105) ATP5B 6 14.6 3.41
ADP/ATP translocase 2 (134) SLC25A5 8 24.8 3.37
Neutrophil elastase (269) ELANE 2 6.7 3.31
Cathepsin G (113) CTSG 5 22.4 3.29
Staphylococcal nuclease domain-containing protein 1 (386) SND1 2 2.5 3.28
Very long chain specific acyl-CoA dehydrogenase (354) ACADVL 2 3.5 3.26
Coatamer subunit gamma-1 (323) COPG1 2 2.6 3.13
Prohibitin-2 (358) PHB2 2 9.7 2.99
Lamin-B1 (396) LMNB1 2 3.4 2.98
Valine—tRNA ligase (299) VARS 2 2.1 2.97
Aspartate aminotransferase, mitochondrial (344) GOT2 2 5.1 2.91
3-Hydroxyacyl-coA dehydrogenase type 2 (267) HSD17B10 2 12.3 2.89
Membrane primary amine oxidase (225) AOC3 4 3.7 −3.04
Keratin type II cytoskeletal 8 (337) KRT8 3 6.2 −3.59
Collagen VIII, α-1 chain (208) COL8A 3 5.0 −3.66
Cochlin (17) COCH 11 20.4 −4.00
Keratin type II cytoskeletal 7 (164) KRT7 6 13.4 −4.70
Tenascin-X (336) TNXB 3 0.8 −4.84
Serum amyloid P-component (93) APCS 5 21.5 −5.96