Table 2 Altered abundances of proteins found in the cholesteatoma matrix proteome relative to healthy ossicles. Positive values indicate increased protein abundance in cholesteatoma. Study ID numbers correlate to Fig. 4
Protein name (study ID number) | NCBI gene ID | Number of unique peptides | Percent protein coverage (%) | Relative protein abundance |
|---|---|---|---|---|
Normal ossicles | ||||
Isocitrate dehydrogenase 2 (199) | IDH2 | 3 | 4.6 | 11.02 |
Creatine kinase B type (187) | CKB | 3 | 9.7 | 7.81 |
Thioredoxin domain-co8ntaining protein 5 (290) | TXNDC5 | 3 | 12.0 | 6.76 |
Cytoskeleton-associated protein 4 (379) | CKAP4 | 2 | 4.8 | 4.64 |
Protein disulfide-isomerase A6 (166) | PDIA6 | 5 | 15.2 | 4.45 |
Ribosome binding protein 1 (251) | RRBP1 | 3 | 2.4 | 4.19 |
Peptidyl-prolyl cis-trans isomerase (368) | FKBP10 | 2 | 4.5 | 4.06 |
ATP synthase subunit α, mitochondrial (97) | ATP5A1 | 9 | 21.2 | 3.92 |
Superoxide dismutase, mitochondrial (377) | SOD2 | 2 | 17.2 | 3.92 |
60S ribosome L14 (298) | RPL14 | 2 | 10.7 | 3.73 |
Stress-10 protein, mitochondrial (290) | HSPA9 | 3 | 12.0 | 3.73 |
Guanine nucleotide binding protein subunit β-2 (283) | GNB2L1 | 4 | 18.3 | 3.63 |
Malate dehydrogenase 2 (165) | MDH2 | 6 | 25.4 | 3.62 |
Serine protease inhibitor H1 (248) | SERPINH1 | 4 | 14.6 | 3.50 |
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase (284) | DDOST | 3 | 7.7 | 3.48 |
Elongation factor Tu (253) | TUFM | 3 | 10.6 | 3.45 |
ATP synthase subunit β, mitochondrial (105) | ATP5B | 6 | 14.6 | 3.41 |
ADP/ATP translocase 2 (134) | SLC25A5 | 8 | 24.8 | 3.37 |
Neutrophil elastase (269) | ELANE | 2 | 6.7 | 3.31 |
Cathepsin G (113) | CTSG | 5 | 22.4 | 3.29 |
Staphylococcal nuclease domain-containing protein 1 (386) | SND1 | 2 | 2.5 | 3.28 |
Very long chain specific acyl-CoA dehydrogenase (354) | ACADVL | 2 | 3.5 | 3.26 |
Coatamer subunit gamma-1 (323) | COPG1 | 2 | 2.6 | 3.13 |
Prohibitin-2 (358) | PHB2 | 2 | 9.7 | 2.99 |
Lamin-B1 (396) | LMNB1 | 2 | 3.4 | 2.98 |
Valine—tRNA ligase (299) | VARS | 2 | 2.1 | 2.97 |
Aspartate aminotransferase, mitochondrial (344) | GOT2 | 2 | 5.1 | 2.91 |
3-Hydroxyacyl-coA dehydrogenase type 2 (267) | HSD17B10 | 2 | 12.3 | 2.89 |
Membrane primary amine oxidase (225) | AOC3 | 4 | 3.7 | −3.04 |
Keratin type II cytoskeletal 8 (337) | KRT8 | 3 | 6.2 | −3.59 |
Collagen VIII, α-1 chain (208) | COL8A | 3 | 5.0 | −3.66 |
Cochlin (17) | COCH | 11 | 20.4 | −4.00 |
Keratin type II cytoskeletal 7 (164) | KRT7 | 6 | 13.4 | −4.70 |
Tenascin-X (336) | TNXB | 3 | 0.8 | −4.84 |
Serum amyloid P-component (93) | APCS | 5 | 21.5 | −5.96 |