Variable | RAI ablation | Without RAI ablation | ||||||
---|---|---|---|---|---|---|---|---|
5 years-DFS | p | 10 years-DFS | p | 5 years-DFS | p | 10 years-DFS | p | |
Age | ||||||||
≤45 years | 97.8 % | 93.5 % | 87.6 % | 83.6 % | ||||
≥45 years | 92.5 % | NS | 85.3 % | NS | 88.5 % | NS | 84.5 % | NS |
Gender | ||||||||
Female | 95.4 % | 91.2 % | 93.8 % | 82.2 % | ||||
Male | 96.8 % | NS | 89.4 % | NS | 90.4 % | NS | 82.0 % | NS |
Histopathologic variants | ||||||||
Classic | 96.1 % | 93.5 % | 95.5 % | 92.3 % | ||||
Follicular | 94.7 % | 90.9 % | 78.9 % | 59.6 % | ||||
Hurthle cell | 96.1 % | 92.7 % | 90.0 % | 0.001 | 78.9 % | <0.001 | ||
Tall cell | 68.2 % | - | - | |||||
Sclerosing | 55.0 % | 0.002 | - | <0.001 | - | |||
Multifocal | ||||||||
Yes | 95.2 % | 90.9 % | 66.7 % | 33.3 % | ||||
No | 96.6 % | NS | 93.4 % | NS | 90.0 % | <0.001 | 88.3 % | <0.0001 |
Surgical margins | ||||||||
Positive | 96.6 % | 91.5 % | 86.3 % | 84.0 % | ||||
Negative | 96.8 % | NS | 95.3 % | NS | 93.2 % | NS | 87.9 % | NS |
ETE | ||||||||
Yes | 89.5 % | 85.5 % | 40.0 % | 0.0 % | ||||
No | 98.2 % | 0.03 | 95.1 % | 0.02 | 91.7 % | <0.0001 | 80.1 % | <0.0001 |
LVSI | ||||||||
Yes | 89.5 % | 85.5 % | 80.0 % | 60.0 % | ||||
No | 92.5 % | NS | 89.4 % | NS | 93.2 % | 0.02 | 84.4 % | 0.001 |
Mean postoperative TG | ||||||||
≤2 ng/ml | 96.6 % | 93.4 % | 93.2 % | 91.7 % | ||||
>2 ng/ml | 89.5 % | NS | 85.5 % | NS | 87.9 % | NS | 80.1 % | 0.04 |
Surgery | ||||||||
Total thyroidectomy | 96.0 % | 94.4 % | 93.2 % | 87.5 % | ||||
Hemi-thyroidectomy | 91.5 % | 0.03 | 86.0 % | 0.03 | 85.1 % | 0.04 | 80.2 % | 0.02 |