|
Variable
|
RAI ablation
|
Without RAI ablation
|
|---|
| |
5 years-DFS
|
p
|
10 years-DFS
|
p
|
5 years-DFS
|
p
|
10 years-DFS
|
p
|
|---|
|
Age
|
|
≤45 years
|
97.8 %
| |
93.5 %
| |
87.6 %
| |
83.6 %
| |
|
≥45 years
|
92.5 %
|
NS
|
85.3 %
|
NS
|
88.5 %
|
NS
|
84.5 %
|
NS
|
|
Gender
|
|
Female
|
95.4 %
| |
91.2 %
| |
93.8 %
| |
82.2 %
| |
|
Male
|
96.8 %
|
NS
|
89.4 %
|
NS
|
90.4 %
|
NS
|
82.0 %
|
NS
|
|
Histopathologic variants
|
|
Classic
|
96.1 %
| |
93.5 %
| |
95.5 %
| |
92.3 %
| |
|
Follicular
|
94.7 %
| |
90.9 %
| |
78.9 %
| |
59.6 %
| |
|
Hurthle cell
|
96.1 %
| |
92.7 %
| |
90.0 %
|
0.001
|
78.9 %
|
<0.001
|
|
Tall cell
|
68.2 %
| |
-
| | |
-
| | |
|
Sclerosing
|
55.0 %
|
0.002
|
-
|
<0.001
| |
-
| | |
|
Multifocal
| | | | | | | | |
|
Yes
|
95.2 %
| |
90.9 %
| |
66.7 %
| |
33.3 %
| |
|
No
|
96.6 %
|
NS
|
93.4 %
|
NS
|
90.0 %
|
<0.001
|
88.3 %
|
<0.0001
|
|
Surgical margins
|
|
Positive
|
96.6 %
| |
91.5 %
| |
86.3 %
| |
84.0 %
| |
|
Negative
|
96.8 %
|
NS
|
95.3 %
|
NS
|
93.2 %
|
NS
|
87.9 %
|
NS
|
|
ETE
|
|
Yes
|
89.5 %
| |
85.5 %
| |
40.0 %
| |
0.0 %
| |
|
No
|
98.2 %
|
0.03
|
95.1 %
|
0.02
|
91.7 %
|
<0.0001
|
80.1 %
|
<0.0001
|
|
LVSI
|
|
Yes
|
89.5 %
| |
85.5 %
| |
80.0 %
| |
60.0 %
| |
|
No
|
92.5 %
|
NS
|
89.4 %
|
NS
|
93.2 %
|
0.02
|
84.4 %
|
0.001
|
|
Mean postoperative TG
|
|
≤2 ng/ml
|
96.6 %
| |
93.4 %
| |
93.2 %
| |
91.7 %
| |
|
>2 ng/ml
|
89.5 %
|
NS
|
85.5 %
|
NS
|
87.9 %
|
NS
|
80.1 %
|
0.04
|
|
Surgery
|
|
Total thyroidectomy
|
96.0 %
| |
94.4 %
| |
93.2 %
| |
87.5 %
| |
|
Hemi-thyroidectomy
|
91.5 %
|
0.03
|
86.0 %
|
0.03
|
85.1 %
|
0.04
|
80.2 %
|
0.02
|
-
RAI radioactive iodine 131, yr year, DFS disease free survival, SD standard deviation, ETE extra-thyroidal extension, LVSI lymphovascular space invasion, TG thyroglobulin
