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Table 4 Cox regression model of various prognostic factors for disease specific survival

From: Adjuvant Radioactive iodine 131 ablation in papillary microcarcinoma of thyroid: Saudi Arabian experience

Variable All patients
Univariate analysis Multivariate analysis
RR (95 % CI) p RR (95 % CI) p
Age
 ≤45 years 1.05 (0.7–1.3)   1.07 (0.8–1.3)  
 ≥45 years 1.10 (0.8–1.4) 0.6 1.10 (0.9–1.3) 0.06
Gender
 Female 1.07 (0.9–1.4)   1.05 (0.7–1.3)  
 Male 1.05 (0.7–1.3) 0.6 1.40 (1.2–1.6) 0.05
Histopathologic variants
 Classic 1.05 (0.7–1.2)   1.20 (0.8–1.6)  
 Follicular 1.00 (0.6–1.8)   1.18 (0.7–1.5)  
 Hurthle cell 1.30 (1.1–1.7)   2.00 (1.6–2.4)  
 Tall cell 2.70 (1.6–4.5)   2.82 (2.4–4.6)  
 Sclerosing 1.80 (1.6–2.9) <0.0001 2.00 (1.6–3.0) <0.0001
Multifocal
 Yes 3.1 (2.8–4.2)   2.94 (2.2–3.4)  
 No 1.0 (0.8–1.2) <0.0001 1.07 (0.9–1.3) <0.0001
Surgical margins
 Positive 1.10 (0.9–1.4)   1.20 (0.8–1.6)  
 Negative 1.07 (0.9–1.4) 0.7 1.17 (0.6–1.2) 0.68
ETE
 Yes 4.2 (3.5–5.1)   3.31 (1.7–4.2)  
 No 1.05 (0.7–1.1) <0.0001 1.17 (0.9–1.4) <0.0001
LVSI
 Yes 2.0 (1.7–2.9)   1.81 (1.6–2.8)  
 No 1.0 (0.8–1.2) 0.02 1.04 (0.9–1.5) 0.03
Lymph nodes
 Positive 4.45 (3.7–6.8)   3.74 (3.4–5.9)  
 Negative 1.17 (0.9–1.4) <0.0001 1.01 (0.8–1.3) <0.0001
Mean postoperative TG
 ≤2 ng/ml 1.01 (0.7–1.2)   1.05 (0.7–1.2)  
 >2 ng/ml 1.04 (0.9–1.5) 0.6 1.00 (0.6–1.8) 0.6
RAI ablation
 Yes 0.35 (0.2–0.7)   0.30 (0.2–0.8)  
 No 1.09 (1.0–1.9) <0.0001 1.00 (0.6–1.8) <0.0001
  1. I-131 radioactive iodine 131, RR relative risk, CI confidence interval, ETE extra-thyroidal extension, LVSI lymphovascular space invasion, TG thyroglobulin, RAI radioactive iodine