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Table 4 Relationship between HR HPV subtype and p16 over-expression

From: HPV DNA in saliva from patients with SCC of the head and neck is specific for p16-positive oropharyngeal tumours

   p16 status      
HR HPV status Positive Negative p-value Sen (95% CI) Spe (95% CI) PPV (95% CI) NPV (95% CI)
Oropharynx Positive 13 0 0.001 76 (50–93) 100 (59–100) 100 (75–100) 64 (30–89)
Negative 4 7
Non-oropharynx Positive 5 2 0.002 80 (28–99) 93 (75–99) 67 (22–96) 96 (80–100)
Negative 1 25
  1. Abbreviations: HR HPV High right human papillomavirus, Sen Sensitivity, Spe Specificity, PPV Positive predictive value, NPV Negative predictive value