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Table 1 Epigenetic regulators specific to OPSCC

From: Epigenetics of oropharyngeal squamous cell carcinoma: opportunities for novel chemotherapeutic targets

Name Description Role in OPSCC Reference
Histone Modifying Proteins
 EZH2 PRC2 protein Hypermethylation of H3K27me3 [90]
 BMI1 PRC1 protein Stabilization of H3K27me3 [90]
DNA Methylation
 DNMT1 DNA methyltrasferase Overexpression [145]
 DNMT3A DNA methyltrasferase Overexpression, de novo methylation [62, 145, 146]
 miR-21 microRNA Overexpression [145]
 miR-205 microRNA Overexpression [145]
 miR-181 microRNA Overexpression [146, 147]
 miR-17–92 cluster microRNA Overexpression [62, 148]
 miR-106b–25 cluster microRNA Overexpression [58, 149]
 miR-106–363 cluster microRNA Overexpression [62]
 Let-7d microRNA Downregulation [66]
  1. a Compared to normal tissues, only miRs frequently associated with cancer diagnosis; EZH2 Enhancer of zeste 2 polycomb repressive complex 2 subunit, DNMT DNA methyltransferase, BMI1 B-cell–specific Moloney murine leukemia virus integration site 1