|
Name
|
Description
|
Role in OPSCC
|
Reference
|
|---|
|
Histone Modifying Proteins
|
|
EZH2
|
PRC2 protein
|
Hypermethylation of H3K27me3
|
[90]
|
|
BMI1
|
PRC1 protein
|
Stabilization of H3K27me3
|
[90]
|
|
DNA Methylation
|
|
DNMT1
|
DNA methyltrasferase
|
Overexpression
|
[145]
|
|
DNMT3A
|
DNA methyltrasferase
|
Overexpression, de novo methylation
|
[62, 145, 146]
|
|
ncRNAsa
|
|
miR-21
|
microRNA
|
Overexpression
|
[145]
|
|
miR-205
|
microRNA
|
Overexpression
|
[145]
|
|
miR-181
|
microRNA
|
Overexpression
|
[146, 147]
|
|
miR-17–92 cluster
|
microRNA
|
Overexpression
|
[62, 148]
|
|
miR-106b–25 cluster
|
microRNA
|
Overexpression
|
[58, 149]
|
|
miR-106–363 cluster
|
microRNA
|
Overexpression
|
[62]
|
|
Let-7d
|
microRNA
|
Downregulation
|
[66]
|
-
a
Compared to normal tissues, only miRs frequently associated with cancer diagnosis; EZH2 Enhancer of zeste 2 polycomb repressive complex 2 subunit, DNMT DNA methyltransferase, BMI1 B-cell–specific Moloney murine leukemia virus integration site 1
