Epigenetics of oropharyngeal squamous cell carcinoma: opportunities for novel chemotherapeutic targets

Table 1 Epigenetic regulators specific to OPSCC

Name	Description	Role in OPSCC	Reference
Histone Modifying Proteins
EZH2	PRC2 protein	Hypermethylation of H3K27me3	[90]
BMI1	PRC1 protein	Stabilization of H3K27me3	[90]
DNA Methylation
DNMT1	DNA methyltrasferase	Overexpression	[145]
DNMT3A	DNA methyltrasferase	Overexpression, de novo methylation	[62, 145, 146]
ncRNAs^a
miR-21	microRNA	Overexpression	[145]
miR-205	microRNA	Overexpression	[145]
miR-181	microRNA	Overexpression	[146, 147]
miR-17–92 cluster	microRNA	Overexpression	[62, 148]
miR-106b–25 cluster	microRNA	Overexpression	[58, 149]
miR-106–363 cluster	microRNA	Overexpression	[62]
Let-7d	microRNA	Downregulation	[66]

^a Compared to normal tissues, only miRs frequently associated with cancer diagnosis; EZH2 Enhancer of zeste 2 polycomb repressive complex 2 subunit, DNMT DNA methyltransferase, BMI1 B-cell–specific Moloney murine leukemia virus integration site 1

ISSN: 1916-0216