Fig. 4

YAP is activated in HPV^+ve-OPSCC. a, b HPV^+ve -OPSCC stained with anti-YAP (a) and Hoechst (b). Note: Solid line is tumor margin (a, b). Boxed regions in (a) are expanded in (c) left box and (e) right box. (c, d) Enlarged region ( left box in a) showing Yap (c) and nuclei (d). Note, Yap is mainly localized to small puncta in the cytosol in tumor margins, with some cells showing YAP accumulation in the nucleus (c, d arrow). e, f Enlarged region (right box in a) showing Yap (e) and nuclei (f). Note, Yap is localized in the nucleus in tumor (e, f, arrows). Scale bar = 50um