Developing a new diagnostic algorithm for human papilloma virus associated oropharyngeal carcinoma: an investigation of HPV DNA assays

Table 1 Assay performance by type of sample

Test	Sample type	Sensitivity	Specificity	Area under curve (ROC)
Cobas® DNA	FNA	91%	82%	0.86 (95% CI 0.75–0.93)
	OP Swab	91%	36%	0.63 (95% CI 0.55–0.75)
	Saliva	100%	69%	0.85 (95% CI 0.75–0.92)
Cervista® HR	FNA	0%	90%	0.45 (95% CI 0.26–0.62)
Cervista® HR	OP swab	100%	33%	0.67 (95% CI 0.45–0.86)
Cervista® HPV Genotype	FNA	0%	86%	0.43 (95% CI 0.25–0.61)
Cervista® HPV Genotype	OP Swab	100%	14%	0.57 (95% CI 0.34–0.77)

HPV Human papilloma virus, DNA Deoxyribonucleic acid, FNA Fine needle aspirate, OP Oropharyngeal

ISSN: 1916-0216