Table 2 Associations of FOXp3 polymorphisms with RRP
| Â | Total (n = 225) | Male (n = 110) | Female (n = 115) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
Case (n = 30) | Control (n = 195) |  | Case (n = 15) | Control (n = 95) |  | Case (n = 15) | Control (n = 100) |  |  | |
n (%) | n (%) | p | n (%) | n (%) | p | n (%) | n (%) | p | OR (95% CI) | |
Age, mean (range) | 41.2 (4–80) | 53.0 (41–71) | ns | 42.5 (4–80) | 55.1 (41–70) | ns | 40.3 (7–69) | 51.0 (41–71) | ns |  |
rs5902434 | ||||||||||
 del/del | 15(50.0) | 99(50.8) | ns | 10(66.7) | 65(68.4) | ns | 5(33.3) | 34(34.0) | ns |  |
 del/ATT | 10(33.3) | 43(22.1) | ns |  |  |  | 10(66.7) | 43(43.0) | 0.043 | 3.1 (1.0–9.7) |
 ATT/ATT | 5(16.7) | 53(27.2) | ns | 5(33.3) | 30(31.6) | ns | 0(0.0) | 23(23.0) | 0.039 | 9.4 (1.1–163.1) |
 del allele | 30(66.7) | 176(59.7) | ns | 10(66.7) | 65(68.4) | ns | 20(66.7) | 111(55.5) | ns |  |
rs3761548 | ||||||||||
 CC | 24(80.0) | 141(72.3) | ns | 12(80.0) | 81(85.3) | ns | 12(80.0) | 60(60.0) | ns |  |
 AC | 3(10.0) | 34(17.4) | ns |  |  |  | 3(20.0) | 34(34.0) | ns |  |
 AA | 3(10.0) | 20(10.3) | ns | 3(20.0) | 14(14.7) | ns | 0(0.0) | 6(6.0) | ns |  |
 C allele | 39(86.7) | 235(79.7) | ns | 12(80.0) | 81(85.3) | ns | 27(90.0) | 154(77.0) | ns |  |
rs3761549 | ||||||||||
 CC | 20(66.7) | 141(72.3) | ns | 13(86.7) | 79(83.2) | ns | 7(46.7) | 62(62.0) | ns |  |
 CT | 8(26.7) | 33(16.9) | ns |  |  |  | 8(53.3) | 33(33.0) | ns |  |
 TT | 2(6.7) | 21(10.8) | ns | 2(13.3) | 16(16.8) | ns | 0(0.0) | 5(5.0) | ns |  |
 T allele | 35(77.8) | 236(80.0) | ns | 13(86.7) | 79(83.2) | ns | 22(73.3) | 157(78.5) | ns |  |
rs2232365 | ||||||||||
 AA | 14(46.7) | 100(51.3) | ns | 10(66.7) | 66(69.5) | ns | 4(26.7) | 34(34.0) | ns |  |
 AG | 11(36.7) | 43(22.1) | ns |  |  |  | 11(73.3) | 43(43.0) | 0.028 | 3.6 (1.1–12.2) |
 GG | 5(16.7) | 52(26.7) | ns | 5(33.3) | 29(30.5) | ns | 0(0.0) | 23(23.0) | 0.039 | 9.4 (1.1–163.1) |
 A allele | 29(64.4) | 177(60.0) | ns | 10(66.7) | 66(69.5) | ns | 19(63.3) | 111(55.5) | ns |  |