|
Subscale (n)
|
Variable
|
Estimate
|
95% CI
|
SE
|
t
|
p
|
SDs of Random Effects
|
|---|
|
Intercept
|
Residual
|
|---|
|
Pain (n = 109)
|
Baseline
|
36.54
|
32.1 to 40.9
|
2.26
|
16.20
| |
17.30
|
14.30
|
|
1 month
|
−13.22
|
−8.7 to −17.8
|
2.32
|
−5.70
|
<.001*
| | |
|
6 month
|
−15.73
|
−11.0 to −21.0
|
2.40
|
−6.55
|
<.001*
| | |
|
1 year
|
−16.07
|
−11.0 to −20.4
|
2.55
|
−6.29
|
<.001*
| | |
|
Swallowing (n = 109)
|
Baseline
|
11.63
|
6.1 to 17.2
|
2.86
|
4.07
| |
12.58
|
16.70
|
|
Sx-RT
|
+6.81
|
−1.0 to +14.7
|
4.00
|
1.70
|
.092
| | |
|
Sx-CRT
|
+10.36
|
+3.1 to +17.7
|
3.70
|
2.80
|
.006
| | |
|
1 month
|
+10.12
|
+4.9 to +15.4
|
2.66
|
3.80
|
<.001*
| | |
|
6 month
|
+5.46
|
0 to +10.8
|
2.76
|
1.98
|
.049
| | |
|
1 year
|
+1.06
|
−4.7 to +6.9
|
2.93
|
.36
|
.719
| | |
|
Senses (n = 109)
|
Baseline
|
16.12
|
11.4 to 20.9
|
2.39
|
6.73
| |
17.99
|
15.54
|
|
1 month
|
+1.57
|
−3.4 to +6.6
|
2.51
|
.63
|
.533
| | |
|
6 month
|
+8.92
|
+3.8 to +14.2
|
2.60
|
3.43
|
<.001*
| | |
|
1 year
|
+2.24
|
−3.1 to +7.8
|
2.77
|
.81
|
.419
| | |
|
Speech (n = 108)
|
Baseline
|
19.93
|
15.9 to 24.1
|
2.09
|
9.53
| |
12.96
|
15.73
|
|
1 month
|
+3.64
|
−1.4 to +8.6
|
2.51
|
1.45
|
.149
| | |
|
6 month
|
+2.78
|
−2.5 to +7.7
|
2.62
|
1.04
|
.302
| | |
|
1 year
|
−.68
|
−6.1 to +4.8
|
2.77
|
−.25
|
.806
| | |
|
Eating (n = 108)
|
Baseline
|
20.50
|
13.2 to 27.8
|
3.69
|
5.55
| |
15.78
|
21.84
|
|
Sx-RT
|
+8.76
|
−1.2 to +18.8
|
5.13
|
1.71
|
.091
| | |
|
Sx-CRT
|
+14.25
|
+5.0 to 23.3
|
4.74
|
3.01
|
.003*
| | |
|
1 month
|
+2.19
|
−4.6 to +9.1
|
3.47
|
.63
|
.528
| | |
|
6 month
|
+3.12
|
−4.0 to +10.3
|
3.63
|
.86
|
.392
| | |
|
1 year
|
−2.95
|
−10.3 to +4.6
|
3.85
|
−.77
|
.445
| | |
|
Social Contact (n = 108)
|
Baseline
|
10.47
|
6.7 to 14.4
|
1.96
|
5.33
| |
13.09
|
14.06
|
|
1 month
|
+4.26
|
−.2 to +8.8
|
2.26
|
1.89
|
.060
| | |
|
6 month
|
+3.97
|
−.6 to +8.5
|
2.35
|
1.69
|
.092
| | |
|
1 year
|
+3.94
|
−.8 to +8.8
|
2.49
|
1.59
|
.114
| | |
|
Sexuality (n = 105)
|
Baseline
|
26.11
|
19.5 to 32.9
|
3.40
|
7.68
| |
22.52
|
23.45
|
|
1 month
|
+1.71
|
−6.1 to +9.5
|
3.93
|
.44
|
.664
| | |
|
6 month
|
+.51
|
−7.6 to +8.4
|
4.07
|
.13
|
.901
| | |
|
1 year
|
−7.38
|
−15.9 to +1.3
|
4.30
|
−1.71
|
.088
| | |
|
Teeth (n = 109)
|
Baseline
|
23.38
|
17.2 to 29.6
|
3.20
|
7.30
| |
16.92
|
26.13
|
|
1 month
|
−3.39
|
−11.5 to +4.9
|
4.19
|
−.81
|
.419
| | |
|
6 month
|
−1.96
|
−10.3 to +6.5
|
4.30
|
−.46
|
.649
| | |
|
1 year
|
+.24
|
−8.8 to +9.3
|
4.64
|
.05
|
.958
| | |
|
Open Mouth (n = 109)
|
Baseline
|
14.65
|
7.4 to 21.9
|
3.71
|
3.94
| |
14.56
|
23.62
|
|
Sx-RT
|
+2.24
|
−7.6 to +12.0
|
5.05
|
.44
|
.659
| | |
|
Sx-CRT
|
+14.59
|
+5.5 to +23.7
|
4.68
|
3.12
|
.002*
| | |
|
1 month
|
+12.42
|
+5.2 to +19.6
|
3.71
|
3.35
|
<.001*
| | |
|
6 month
|
+11.30
|
+3.7 to +18.9
|
3.88
|
2.92
|
.004
| | |
|
1 year
|
+2.86
|
−5.3 to +11.0
|
4.13
|
.69
|
.490
| | |
|
Dry Mouth (n = 109)
|
Baseline
|
28.91
|
19.2 to 38.5
|
4.93
|
5.86
| |
18.26
|
24.89
|
|
Sx-RT
|
−15.39
|
−31.2 to +.6
|
8.05
|
−1.91
|
.057
| | |
|
Sx-CRT
|
−6.05
|
−20.4 to +8.4
|
7.32
|
−.83
|
.409
| | |
|
1 m x Sx
|
+8.23
|
−4.0 to +20.1
|
6.13
|
1.34
|
.180
| | |
|
6 m x Sx
|
+5.08
|
−7.4 to +17.5
|
6.39
|
.80
|
.428
| | |
|
1y x Sx
|
+6.16
|
−7.1 to +20.0
|
6.87
|
.90
|
.371
| | |
|
1 m x Sx-RT
|
+3.83
|
−15.5 to +23.7
|
10.11
|
.38
|
.705
| | |
|
6 m x Sx-RT
|
+42.18
|
+22.5 to +62.9
|
10.18
|
4.14
|
<.001*
| | |
|
1y x Sx-RT
|
+35.27
|
+13.7 to +56.9
|
10.96
|
3.22
|
.001*
| | |
|
1 m x Sx-CRT
|
+14.88
|
−3.0 to +32.5
|
9.12
|
1.63
|
.104
| | |
|
6 m x Sx-CRT
|
+36.45
|
+17.8 to +55.0
|
9.63
|
3.79
|
<.001*
| | |
|
1y x Sx-CRT
|
+33.03
|
+13.0 to +52.6
|
10.18
|
3.25
|
.001*
| | |
|
Sticky Saliva (n = 109)
|
Baseline
|
25.74
|
19.3 to 32.3
|
3.34
|
7.72
| |
18.80
|
26.18
|
|
1 month
|
+7.69
|
−.7 to +15.8
|
4.17
|
1.85
|
.066
| | |
|
6 month
|
+15.30
|
+6.7 to +23.9
|
4.35
|
3.53
|
<.001*
| | |
|
1 year
|
+15.34
|
+6.2 to +24.5
|
4.63
|
3.33
|
.001*
| | |
|
Cough (n = 109)
|
Baseline
|
17.74
|
13.4 to 22.0
|
2.20
|
8.05
| |
12.20
|
17.56
|
|
1 month
|
+3.82
|
−1.4 to +9.2
|
2.78
|
1.38
|
.170
| | |
|
6 month
|
+6.28
|
+.5 to +12.0
|
2.90
|
2.16
|
.032
| | |
|
1 year
|
−3.08
|
−9.2 to +3.00
|
3.08
|
−1.00
|
.318
| | |
-
Note. *p < .0028; Models with treatment, time, and treatment x time interaction: Baseline = pre-operative mean estimate for surgery only group; Sx-RT/Sx-CRT = difference between pre-operative mean scores and baseline for surgery and radiotherapy, and, surgery and chemoradiotherapy groups, respectively; 1 m/6 m/1y x Sx/Sx-RT/Sx-CRT = difference between mean subscale scores and baseline at 1 month, 6 months, and 1 year post-operation, respectively, for the surgery only, surgery and radiotherapy, and, surgery and chemoradiotherapy groups, respectively; Models with treatment and time (no interaction term): Baseline = pre-operative mean estimate for surgery only group; Sx-RT,/Sx-CRT = difference between pre-operative mean scores and baseline for surgery and radiotherapy, and, surgery and chemoradiotherapy groups, respectively; 1 month/6 months/1 year = difference between mean subscale scores and baseline for respective assessment time point for combined cohort; Models with time variable only: Baseline = pre-operative mean estimate for subscale scores for combined cohort; 1 month/6 months/1 year = difference between mean subscale scores and baseline for respective assessment time point for combined cohort; p-value for baseline scores not provided given that it tests the hypothesis that the baseline mean is significantly different from 0, results of which are not clinically meaningful; 95% CI calculated using bootstrapping approach
