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Table 4 Mixed effects linear regression models for EORTC Quality of Life Questionnaire Head and Neck Module (EORTC-H&N35)

From: Functional and quality of life outcomes after partial glossectomy: a multi-institutional longitudinal study of the head and neck research network

Subscale (n)

Variable

Estimate

95% CI

SE

t

p

SDs of Random Effects

Intercept

Residual

Pain (n = 109)

Baseline

36.54

32.1 to 40.9

2.26

16.20

 

17.30

14.30

1 month

−13.22

−8.7 to −17.8

2.32

−5.70

<.001*

  

6 month

−15.73

−11.0 to −21.0

2.40

−6.55

<.001*

  

1 year

−16.07

−11.0 to −20.4

2.55

−6.29

<.001*

  

Swallowing (n = 109)

Baseline

11.63

6.1 to 17.2

2.86

4.07

 

12.58

16.70

Sx-RT

+6.81

−1.0 to +14.7

4.00

1.70

.092

  

Sx-CRT

+10.36

+3.1 to +17.7

3.70

2.80

.006

  

1 month

+10.12

+4.9 to +15.4

2.66

3.80

<.001*

  

6 month

+5.46

0 to +10.8

2.76

1.98

.049

  

1 year

+1.06

−4.7 to +6.9

2.93

.36

.719

  

Senses (n = 109)

Baseline

16.12

11.4 to 20.9

2.39

6.73

 

17.99

15.54

1 month

+1.57

−3.4 to +6.6

2.51

.63

.533

  

6 month

+8.92

+3.8 to +14.2

2.60

3.43

<.001*

  

1 year

+2.24

−3.1 to +7.8

2.77

.81

.419

  

Speech (n = 108)

Baseline

19.93

15.9 to 24.1

2.09

9.53

 

12.96

15.73

1 month

+3.64

−1.4 to +8.6

2.51

1.45

.149

  

6 month

+2.78

−2.5 to +7.7

2.62

1.04

.302

  

1 year

−.68

−6.1 to +4.8

2.77

−.25

.806

  

Eating (n = 108)

Baseline

20.50

13.2 to 27.8

3.69

5.55

 

15.78

21.84

Sx-RT

+8.76

−1.2 to +18.8

5.13

1.71

.091

  

Sx-CRT

+14.25

+5.0 to 23.3

4.74

3.01

.003*

  

1 month

+2.19

−4.6 to +9.1

3.47

.63

.528

  

6 month

+3.12

−4.0 to +10.3

3.63

.86

.392

  

1 year

−2.95

−10.3 to +4.6

3.85

−.77

.445

  

Social Contact (n = 108)

Baseline

10.47

6.7 to 14.4

1.96

5.33

 

13.09

14.06

1 month

+4.26

−.2 to +8.8

2.26

1.89

.060

  

6 month

+3.97

−.6 to +8.5

2.35

1.69

.092

  

1 year

+3.94

−.8 to +8.8

2.49

1.59

.114

  

Sexuality (n = 105)

Baseline

26.11

19.5 to 32.9

3.40

7.68

 

22.52

23.45

1 month

+1.71

−6.1 to +9.5

3.93

.44

.664

  

6 month

+.51

−7.6 to +8.4

4.07

.13

.901

  

1 year

−7.38

−15.9 to +1.3

4.30

−1.71

.088

  

Teeth (n = 109)

Baseline

23.38

17.2 to 29.6

3.20

7.30

 

16.92

26.13

1 month

−3.39

−11.5 to +4.9

4.19

−.81

.419

  

6 month

−1.96

−10.3 to +6.5

4.30

−.46

.649

  

1 year

+.24

−8.8 to +9.3

4.64

.05

.958

  

Open Mouth (n = 109)

Baseline

14.65

7.4 to 21.9

3.71

3.94

 

14.56

23.62

Sx-RT

+2.24

−7.6 to +12.0

5.05

.44

.659

  

Sx-CRT

+14.59

+5.5 to +23.7

4.68

3.12

.002*

  

1 month

+12.42

+5.2 to +19.6

3.71

3.35

<.001*

  

6 month

+11.30

+3.7 to +18.9

3.88

2.92

.004

  

1 year

+2.86

−5.3 to +11.0

4.13

.69

.490

  

Dry Mouth (n = 109)

Baseline

28.91

19.2 to 38.5

4.93

5.86

 

18.26

24.89

Sx-RT

−15.39

−31.2 to +.6

8.05

−1.91

.057

  

Sx-CRT

−6.05

−20.4 to +8.4

7.32

−.83

.409

  

1 m x Sx

+8.23

−4.0 to +20.1

6.13

1.34

.180

  

6 m x Sx

+5.08

−7.4 to +17.5

6.39

.80

.428

  

1y x Sx

+6.16

−7.1 to +20.0

6.87

.90

.371

  

1 m x Sx-RT

+3.83

−15.5 to +23.7

10.11

.38

.705

  

6 m x Sx-RT

+42.18

+22.5 to +62.9

10.18

4.14

<.001*

  

1y x Sx-RT

+35.27

+13.7 to +56.9

10.96

3.22

.001*

  

1 m x Sx-CRT

+14.88

−3.0 to +32.5

9.12

1.63

.104

  

6 m x Sx-CRT

+36.45

+17.8 to +55.0

9.63

3.79

<.001*

  

1y x Sx-CRT

+33.03

+13.0 to +52.6

10.18

3.25

.001*

  

Sticky Saliva (n = 109)

Baseline

25.74

19.3 to 32.3

3.34

7.72

 

18.80

26.18

1 month

+7.69

−.7 to +15.8

4.17

1.85

.066

  

6 month

+15.30

+6.7 to +23.9

4.35

3.53

<.001*

  

1 year

+15.34

+6.2 to +24.5

4.63

3.33

.001*

  

Cough (n = 109)

Baseline

17.74

13.4 to 22.0

2.20

8.05

 

12.20

17.56

1 month

+3.82

−1.4 to +9.2

2.78

1.38

.170

  

6 month

+6.28

+.5 to +12.0

2.90

2.16

.032

  

1 year

−3.08

−9.2 to +3.00

3.08

−1.00

.318

  
  1. Note. *p < .0028; Models with treatment, time, and treatment x time interaction: Baseline = pre-operative mean estimate for surgery only group; Sx-RT/Sx-CRT = difference between pre-operative mean scores and baseline for surgery and radiotherapy, and, surgery and chemoradiotherapy groups, respectively; 1 m/6 m/1y x Sx/Sx-RT/Sx-CRT = difference between mean subscale scores and baseline at 1 month, 6 months, and 1 year post-operation, respectively, for the surgery only, surgery and radiotherapy, and, surgery and chemoradiotherapy groups, respectively; Models with treatment and time (no interaction term): Baseline = pre-operative mean estimate for surgery only group; Sx-RT,/Sx-CRT = difference between pre-operative mean scores and baseline for surgery and radiotherapy, and, surgery and chemoradiotherapy groups, respectively; 1 month/6 months/1 year = difference between mean subscale scores and baseline for respective assessment time point for combined cohort; Models with time variable only: Baseline = pre-operative mean estimate for subscale scores for combined cohort; 1 month/6 months/1 year = difference between mean subscale scores and baseline for respective assessment time point for combined cohort; p-value for baseline scores not provided given that it tests the hypothesis that the baseline mean is significantly different from 0, results of which are not clinically meaningful; 95% CI calculated using bootstrapping approach
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Journal of Otolaryngology - Head & Neck Surgery

ISSN: 1916-0216

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