TY - JOUR AU - Nhan, Carol AU - Bezdjian, Aren AU - Saha, Shyamali AU - Prakash, Satya AU - Nguyen, Lily H. P. AU - Daniel, Sam J. PY - 2017 DA - 2017/11/22 TI - Safety of transtympanic application of probiotics in a chinchilla animal model JO - Journal of Otolaryngology - Head & Neck Surgery SP - 63 VL - 46 IS - 1 AB - Chronic suppurative otitis media can be recalcitrant and difficult to treat, particularly with the increasing occurrence of antibiotic resistance. Lactobacillus plantarum is a probiotic that has been shown to decrease S. aureus and P. aeruginosa growth in wounds, making it a good candidate for the treatment of chronic suppurative otitis media. However, before it can be applied in the ear, its ototoxicity potential must be evaluated. SN - 1916-0216 UR - https://doi.org/10.1186/s40463-017-0242-y DO - 10.1186/s40463-017-0242-y ID - Nhan2017 ER -