Skip to main content

Table 1 Summary of included studies

From: The prevalence of human papillomavirus in pediatric tonsils: a systematic review of the literature

First Study Author & Year of Publicationa

Country

# of Patients

Age Range (Years) [mean]

Prevalence of HPVa

Testing Method

Types of HPV Tested

Types of HPV Found

Cockerill, CC (2016) [25] [full text] b

USA

129

1ā€“12 [NR]

0%

Biopsy + swabs + Roche Cobas Amplicor test qPCR & E6/E7 Gene-Probe Aptima HPV test

16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68

None

Palmer, E (2014) [27] [full text]

United Kingdom

1670

0ā€“18 [NR]

0%

Biopsy + GP5+/6+ primer PCR enzyme immunoassay + PCR E6 gene targeting for HPV16

20 types (unspecified), 14 high-risk and 6 low-risk

None

Xue, XC (2014) [26] [full text]

China

42

3ā€“12 [6.8]

0%

Biopsy + MY09/11 primer qPCR

6, 11, 16, 18, 26, 31, 33ā€“35, 39, 40, 42ā€“45, 51ā€“59, 61, 66ā€“73, 81ā€“84

None

Sun, YF (2012) [abstract] [article in Chinese] [14] [full text]

China

177

NR[NR]

1%

Biopsy + PCR (unspecified)

NR

6, 11

Duray, A (2011) [19] [full text]

Belgium

42

0ā€“15 [NR]

21%

Biopsy + GP5+/GP6+ primer PCRā€‰+ā€‰E6/E7 type-specific qPCR for multiple HPV subtypes

6, 11, 16, 18, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 68

16, NR

Baloglu, H (2010) [17] [full text]

Turkey

165

5ā€“21 [11.9]

7%

Biopsy + MY/GP PCRā€‰+ā€‰E6/E7 type-specific PCR

6, 11, 16, 18, 31, 33, 35, 39, 42, 43, 44, 45, 51, 52, 56, 58, 59, 66, 68

6, 11, 16, 31

SoldatskiÄ­, IuA (2009) [abstract] [article in Russian] [13]

Russia

8

2ā€“14 [6.8]

13%

PCR

6, 11, 16, 18, 31, 33

NR

Mammas, IN (2006) [20] [full text]

Greece

64

2ā€“14 [7.1]

9%

Biopsy + GP5+/6+ primer PCRā€‰+ā€‰type-specific PCR for multiple HPV subtypes

11, 16, 18, 33

16, NR

Sisk, J (2006) [18] [full text]

USA

50

3ā€“12 [NR]

4%

Biopsy + MY09/11 primer PCR

NR

11

Ribeiro, KM (2006) [37] [full text]

Brazil

100

2ā€“13 [NR]

0%

Biopsy + MY09/11 primer PCR

NR

None

Chen, R (2005) [21] [full text]

Finland

73

1ā€“16 [8.3]

8%

Biopsy + GP5+/6+ & MY09/11 primer PCRā€‰+ā€‰type-specific testing

NR

16

  1. HPV human papillomavirus, NR not reported in the study or for the tonsillectomy portion
  2. a Articles published in English unless otherwise specified
  3. b This study only assessed high-risk HPV subtypes. This was also the only study to report that some patients had been vaccinated against HPV; 6 (4.7%) of patients had received the vaccine