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Table 2 Toxicities occurring in patients treated with cisplatin and 5-FU

From: Renal protective effect of a hydration supplemented with magnesium in patients receiving cisplatin for head and neck cancer

  Magnesium -supplemented regimen (n = 56) Crystalloid-only regimen with aprepitant (n = 22) Crystalloid-only regimen without aprepitant (n = 43) P value*
Nausea
 Grade 1–2 30 (53.6%) 7 (31.8%) 29 (67.4%) 0.010
 Grade 3 2 (3.6%) 1 (2.3%) 5 (11.6%)
Vomitting
 Grade 1–2 2 (3.6%) 2 (4.6%) 6 (14.0%) 0.175
 Grade 3 0 (0%) 0 (0%) 0 (0%)
Dehydration
 Grade 1–2 5 (8.9%) 2 (4.7%) 12 (27.9%) 0.017
 Grade 3 6 (10.7%) 2 (4.7%) 9 (20.9%)
  1. Toxicities were graded using the Common Terminology Criteria for Adverse Event version 4.0
  2. *Chi-square test