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Table 2 Toxicities occurring in patients treated with cisplatin and 5-FU

From: Renal protective effect of a hydration supplemented with magnesium in patients receiving cisplatin for head and neck cancer

 

Magnesium -supplemented regimen (n = 56)

Crystalloid-only regimen with aprepitant (n = 22)

Crystalloid-only regimen without aprepitant (n = 43)

P value*

Nausea

 Grade 1–2

30 (53.6%)

7 (31.8%)

29 (67.4%)

0.010

 Grade 3

2 (3.6%)

1 (2.3%)

5 (11.6%)

Vomitting

 Grade 1–2

2 (3.6%)

2 (4.6%)

6 (14.0%)

0.175

 Grade 3

0 (0%)

0 (0%)

0 (0%)

Dehydration

 Grade 1–2

5 (8.9%)

2 (4.7%)

12 (27.9%)

0.017

 Grade 3

6 (10.7%)

2 (4.7%)

9 (20.9%)

  1. Toxicities were graded using the Common Terminology Criteria for Adverse Event version 4.0
  2. *Chi-square test