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Table 3 Characteristics of patients classified by nephrotoxicity caused by cisplatin

From: Renal protective effect of a hydration supplemented with magnesium in patients receiving cisplatin for head and neck cancer

Characteristics   Nephrotoxicity- Nephrotoxicity+ P value*
Age < 65 40 (42.6) 12 (44.4) 1.0000
≥ 65 54 (57.4) 15 (55.6)
Sex female 13 (13.8) 6 (22.2) 0.3671
male 81 (86.2) 21 (77.8)
Primary site Hypopharynx 23 (24.5) 9 (33.3) 0.4578
Others 71 (75.5) 18 (66.7)
Ccr < 120 mL/min 86 (79.3) 22 (20.4) 0.1619
≥ 120 mL/min 8 (61.2) 5 (38.4)
Albumin < 4 g/mL 32 (34.4) 12 (44.4) 0.3674
≥ 4 g/mL 62 (66) 15 (55.6)
Aprepitant 25 (26.6) 18 (66.7) 0.0002
+ 69 (73.4) 9 (33.3)
Regimen Crystalloid-only 41 (43.6) 24 (88.9) < 0.0001
Magnesium-supplemented 53 (56.4) 3 (11.1)
  1. Nephrotoxicity+ is defined as the 20% reduction in creatinine clearance after two courses
  2. Ccr Creatinine clearance
  3. *Fisher’s exact test