|
Characteristics
| |
Nephrotoxicity-
|
Nephrotoxicity+
|
P value*
|
|---|
|
Age
|
< 65
|
40 (42.6)
|
12 (44.4)
|
1.0000
|
|
≥ 65
|
54 (57.4)
|
15 (55.6)
|
|
Sex
|
female
|
13 (13.8)
|
6 (22.2)
|
0.3671
|
|
male
|
81 (86.2)
|
21 (77.8)
|
|
Primary site
|
Hypopharynx
|
23 (24.5)
|
9 (33.3)
|
0.4578
|
|
Others
|
71 (75.5)
|
18 (66.7)
|
|
Ccr
|
< 120 mL/min
|
86 (79.3)
|
22 (20.4)
|
0.1619
|
|
≥ 120 mL/min
|
8 (61.2)
|
5 (38.4)
|
|
Albumin
|
< 4 g/mL
|
32 (34.4)
|
12 (44.4)
|
0.3674
|
|
≥ 4 g/mL
|
62 (66)
|
15 (55.6)
|
|
Aprepitant
|
–
|
25 (26.6)
|
18 (66.7)
|
0.0002
|
|
+
|
69 (73.4)
|
9 (33.3)
|
|
Regimen
|
Crystalloid-only
|
41 (43.6)
|
24 (88.9)
|
< 0.0001
|
|
Magnesium-supplemented
|
53 (56.4)
|
3 (11.1)
|
- Nephrotoxicity+ is defined as the 20% reduction in creatinine clearance after two courses
- Ccr Creatinine clearance
- *Fisher’s exact test
