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Table 1 Clinicopathological characteristics of the study population

From: Prognostic significance of cell cycle-associated proteins p16, pRB, cyclin D1 and p53 in resected oropharyngeal carcinoma

Characteristic Entire cohort (n = 313) Resection only group (n = 104) Resection with adjuvant therapy group (n = 209)
Mean age (range) 68 (35–101) 68 (47–101) 68 (35–100)
Gender
 Male 230 (73.5%) 71 (68.3%) 159 (76.1%)
 Female 83 (26.5%) 33 (31.7%) 50 (23.9%)
Smoking history
  > 10 pack-years 221 (70.6%) 78 (75.0%) 143 (68.4%)
  < 10 pack-years 92 (29.4%) 26 (25.0%) 66 (31.6%)
Alcohol intake
  < 3 U/d 164 (52.4%) 52 (50.0%) 112 (53.6%)
  > 3 U/d 113 (36.1%) 40 (38.5%) 73 (34.9%)
 Missing data 36 (11.5%) 12 (11.5%) 24 (11.5%)
Primary site
 Tonsil 217 (69.3%) 68 (65.4%) 149 (71.3%)
 Base of tongue 58(18.5%) 16 (15.4%) 42 (20.1%)
 Posterior wall / soft palate 38 (12.2%) 20 (19.2%) 18 (8.6%)
Tumor stage
 T1/T2 263 (84.0%) 96 (92.3%) 167 (79.9%)
 T3/T4 50 (16.0%) 8 (7.7%) 42 (20.1%)
Nodal stage
 N0 92 (29.4%) 58 (55.8%) 34 (16.3%)
 N+ 221 (70.6%) 46 (44.2%) 175 (83.7%)
HR-HPV DNA
 Positive 158 (50.5%) 42 (40.4%) 116 (55.5%)
 Negative 155 (49.5%) 62 (59.6%) 93 (44.5%)
5-year overall survival rate 76.1% 69.8% 79.1%
5-year disease-specific survival rate 85.2% 83.1% 86.2%