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Table 2 Association between cell cycle protein expression and HR-HPV DNA status

From: Prognostic significance of cell cycle-associated proteins p16, pRB, cyclin D1 and p53 in resected oropharyngeal carcinoma

Cell cycle protein Entire cohort HR-HPV DNA negative HR-HPV DNA positive Pearson Chi-square Sensitivity (%) Specificity (%) PPV (%) NPV (%) DOR
  (n = 313) (n = 155) All (n = 158) HPV16 (n = 147) Non-HPV16 (n = 11) p value      
p16INK4a < 0.001 91.8 89.0 89.5 91.4 90.3
 Low 151 (48.2%) 138 (89.0%) 13 (8.2%) 13 (8.8%) 0 (0%)
 High 162 (51.8%) 17 (11.0%) 145 (91.8%) 134 (91.2%) 11 (100.0%)
pRB < 0.001 82.9 86.5 86.2 83.2 31.1
 Low 152 (48.6%) 21 (13.5%) 131 (82.9%) 121 (82.3%) 10 (91.0%)
 High 161 (51.4%) 134 (86.5%) 27 (17.1%) 26 (17.7%) 1 (9.0%)
Cyclin D1 < 0.001 84.2 68.4 73.1 80.9 11.5
 Low 181 (57.8%) 48 (31%) 133 (84.2%) 124 (84.3%) 9 (81.8%)
 High 132 (42.2%) 107 (69%) 25 (15.8%) 23 (15.7%) 2 (18.2%)
p53 < 0.001 85.4 53.9 64.9 78.1 6.8
 Low 208 (66.5%) 73 (47.1%) 135 (85.4%) 127 (86.4%) 8 (72.7%)
 High 105 (33.5%) 82 (52.9%) 23 (14.6%) 20 (13.6%) 3 (27.3%)
p16INK4a/pRB < 0.001 82.9 92.9 92.3 84.2 63.8
 High/low 142 (45.4%) 11 (7.1%) 131 (82.9%) 121 (82.3%) 10 (90.9%)
 Other 171 (54.6%) 144 (92.9%) 27 (17.1%) 26 (17.7%) 1 (9.1%)
p16 INK4a/pRB/ cyclin D1/p53 < 0.001 68.4 93.5 91.5 74.4 30.9
 High/low/low/low 118 (37.7%) 10 (6.5%) 108 (68.4%) 102 (69.4%) 6 (54.6%)
 Other 195 (62.3%) 145 (93.5%) 50 (31.6%) 45 (30.6%) 5 (45.4%)
  1. PPV positive predictive value, NPV negative predictive value (%); and DOR diagnostic odds ratio. Non-HPV16 group included tumors positive for HPV18, HPV33, HPV35, HPV56, or HPV59