Table 2 Association between cell cycle protein expression and HR-HPV DNA status
Cell cycle protein | Entire cohort | HR-HPV DNA negative | HR-HPV DNA positive | Pearson Chi-square | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | DOR | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
(n = 313) | (n = 155) | All (n = 158) | HPV16 (n = 147) | Non-HPV16 (n = 11) | p value | ||||||
p16INK4a | < 0.001 | 91.8 | 89.0 | 89.5 | 91.4 | 90.3 | |||||
Low | 151 (48.2%) | 138 (89.0%) | 13 (8.2%) | 13 (8.8%) | 0 (0%) | ||||||
High | 162 (51.8%) | 17 (11.0%) | 145 (91.8%) | 134 (91.2%) | 11 (100.0%) | ||||||
pRB | < 0.001 | 82.9 | 86.5 | 86.2 | 83.2 | 31.1 | |||||
Low | 152 (48.6%) | 21 (13.5%) | 131 (82.9%) | 121 (82.3%) | 10 (91.0%) | ||||||
High | 161 (51.4%) | 134 (86.5%) | 27 (17.1%) | 26 (17.7%) | 1 (9.0%) | ||||||
Cyclin D1 | < 0.001 | 84.2 | 68.4 | 73.1 | 80.9 | 11.5 | |||||
Low | 181 (57.8%) | 48 (31%) | 133 (84.2%) | 124 (84.3%) | 9 (81.8%) | ||||||
High | 132 (42.2%) | 107 (69%) | 25 (15.8%) | 23 (15.7%) | 2 (18.2%) | ||||||
p53 | < 0.001 | 85.4 | 53.9 | 64.9 | 78.1 | 6.8 | |||||
Low | 208 (66.5%) | 73 (47.1%) | 135 (85.4%) | 127 (86.4%) | 8 (72.7%) | ||||||
High | 105 (33.5%) | 82 (52.9%) | 23 (14.6%) | 20 (13.6%) | 3 (27.3%) | ||||||
p16INK4a/pRB | < 0.001 | 82.9 | 92.9 | 92.3 | 84.2 | 63.8 | |||||
High/low | 142 (45.4%) | 11 (7.1%) | 131 (82.9%) | 121 (82.3%) | 10 (90.9%) | ||||||
Other | 171 (54.6%) | 144 (92.9%) | 27 (17.1%) | 26 (17.7%) | 1 (9.1%) | ||||||
p16 INK4a/pRB/ cyclin D1/p53 | < 0.001 | 68.4 | 93.5 | 91.5 | 74.4 | 30.9 | |||||
High/low/low/low | 118 (37.7%) | 10 (6.5%) | 108 (68.4%) | 102 (69.4%) | 6 (54.6%) | ||||||
Other | 195 (62.3%) | 145 (93.5%) | 50 (31.6%) | 45 (30.6%) | 5 (45.4%) | ||||||