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Table 3 Univariate analysis of overall and disease-specific survival for patients with OPSCC patients treated with resection

From: Prognostic significance of cell cycle-associated proteins p16, pRB, cyclin D1 and p53 in resected oropharyngeal carcinoma

N = 313 5-year overall survival 5-year disease-specific survival
Parameter % P value HR (95% CI) P value % P value HR (95% CI) P value
Age (> 65 y vs. < 65 y) 75.6/77.1 0.83 1.05 (0.66–1.68) 0.83 85.3/84.9 0.88 1.05 (0.56–1.99) 0.88
Smoking history (> 10 py vs. < 10 py) 70.9/88.5 0.002 2.53 (1.37–4.69) 0.003 80.8/95.8 0.003 4.19 (1.49–11.77) 0.006
Tumor stage (T3/T4 vs. T1/T2) 64.7/78.5 0.15 1.48 (0.87–2.55) 0.15 74.6/87.4 0.023 2.15 (1.09–4.21) 0.03
Nodal stage (N+ vs. N0) 73.5/82.0 0.31 1.3 (0.78–2.16) 0.31 83.2/90.2 0.14 1.77 (0.82–3.84) 0.15
HR-HPV DNA (Positive vs. negative) 85.9/66.8 < 0.001 0.39 (0.24–0.64) < 0.001 91.6/78.9 < 0.001 0.30 (0.15–0.62) 0.001
p16INK4a (High vs. low) 89.6/64.5 < 0.001 0.29 (0.15–0.44) < 0.001 93.2/80.9 < 0.001 0.21 (0.1–0.46) < 0.001
pRB (High vs. low) 67.6/85.5 < 0.001 2.68 (1.63–4.43) < 0.001 78.8/92.2 < 0.001 3.56 (1.70–7.47) 0.001
Cyclin D1 (High vs. low) 67.6/82.0 0.009 1,79 (1.15–2.80) 0.01 81.9/87.7 0.068 1.76 (0.95–3.25) 0.07
p53 (High vs. low) 66.2/81.2 0.002 1.99 (1.27–3.10) 0.002 79.1/88.2 0.053 1.82 (0.98–3.36) 0.06
High p16INK4a/HR-HPV DNA positive vs. others 85.9/66.8 < 0.001 0.39 (0.24–0.64) < 0.001 91.6/78.9 < 0.001 0.30 (0.15–0.62) 0.001
High p16INK4a/low pRB vs. others 87.7/67.0 < 0.001 0.32(0.18–0.54) < 0.001 93.2/78.7 < 0.001 0.23 (0.10–0.52) < 0.001
High p16INK4a/low pRB/low cyclin D1/low p53 vs. others 88.3/69.9 < 0.001 0.33 (0.18–0.59) < 0.001 94.1/80.0 < 0.001 0.21 (0.08–0.55) 0.001
  1. Abbreviations: HR hazard ratio for death, CI confidence interval; py pack-year. Log-rank test. p < 0.05 was considered statistically significant