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Table 2 Distribution of RAS and BRAF mutations identified by ddPCR according to Bethesda classification

From: Analytic and clinical validity of thyroid nodule mutational profiling using droplet digital polymerase chain reaction

Bethesda

Low RNA

HRAS

G12 V

HRAS

Q61R

HRAS

Q61K

NRAS

Q61R

NRAS

Q61K

BRAF

V600E

1-Non Dx

N = 56 (26.9)

5

9

6

6

2

1

1

2-Benign

N = 115 (55.2)

11

20

28

6

11

2

1

3-FLUS/AUS

N = 11 (5.3)

2

2

2

2

1

1

1

4-FN/SFN

N = 6 (2.9)

0

1

1

0

1

0

0

5-SFM

N = 5 (2.4)

1

1

1

0

1

0

2

6-Malignant

N = 15 (7.2)

0

3

3

0

2

0

9

Total (%)

19 (9.1)

36 (17.3)

41 (19.7)

14 (6.7)

18 (8.2)

4 (1.9)

14 (6.7)

  1. Low RNA column indicates FNAB samples with RNA/nucleic acid < 1 ng, not used for ddPCR analysis
  2. Dx diagnostic, AUS/FLUS atypia of uncertain significance/follicular lesion of undetermined significance, FN/SFN follicular neoplasm/suspicious for follicular neoplasm, SFM suspicious for malignancy
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Journal of Otolaryngology - Head & Neck Surgery

ISSN: 1916-0216

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