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Table 2 Distribution of RAS and BRAF mutations identified by ddPCR according to Bethesda classification

From: Analytic and clinical validity of thyroid nodule mutational profiling using droplet digital polymerase chain reaction

Bethesda Low RNA HRAS
G12 V
HRAS
Q61R
HRAS
Q61K
NRAS
Q61R
NRAS
Q61K
BRAF
V600E
1-Non Dx
N = 56 (26.9)
5 9 6 6 2 1 1
2-Benign
N = 115 (55.2)
11 20 28 6 11 2 1
3-FLUS/AUS
N = 11 (5.3)
2 2 2 2 1 1 1
4-FN/SFN
N = 6 (2.9)
0 1 1 0 1 0 0
5-SFM
N = 5 (2.4)
1 1 1 0 1 0 2
6-Malignant
N = 15 (7.2)
0 3 3 0 2 0 9
Total (%) 19 (9.1) 36 (17.3) 41 (19.7) 14 (6.7) 18 (8.2) 4 (1.9) 14 (6.7)
  1. Low RNA column indicates FNAB samples with RNA/nucleic acid < 1 ng, not used for ddPCR analysis
  2. Dx diagnostic, AUS/FLUS atypia of uncertain significance/follicular lesion of undetermined significance, FN/SFN follicular neoplasm/suspicious for follicular neoplasm, SFM suspicious for malignancy