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Table 2 Distribution of RAS and BRAF mutations identified by ddPCR according to Bethesda classification

From: Analytic and clinical validity of thyroid nodule mutational profiling using droplet digital polymerase chain reaction

Bethesda Low RNA HRAS G12 V HRAS Q61R HRAS Q61K NRAS Q61R NRAS Q61K BRAF V600E
1-Non Dx N = 56 (26.9) 5 9 6 6 2 1 1
2-Benign N = 115 (55.2) 11 20 28 6 11 2 1
3-FLUS/AUS N = 11 (5.3) 2 2 2 2 1 1 1
4-FN/SFN N = 6 (2.9) 0 1 1 0 1 0 0
5-SFM N = 5 (2.4) 1 1 1 0 1 0 2
6-Malignant N = 15 (7.2) 0 3 3 0 2 0 9
Total (%) 19 (9.1) 36 (17.3) 41 (19.7) 14 (6.7) 18 (8.2) 4 (1.9) 14 (6.7)
  1. Low RNA column indicates FNAB samples with RNA/nucleic acid < 1 ng, not used for ddPCR analysis
  2. Dx diagnostic, AUS/FLUS atypia of uncertain significance/follicular lesion of undetermined significance, FN/SFN follicular neoplasm/suspicious for follicular neoplasm, SFM suspicious for malignancy