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Table 3 Distribution of pre-operative fine needle aspirate cytology and ddPCR mutation results in surgical specimen

From: Analytic and clinical validity of thyroid nodule mutational profiling using droplet digital polymerase chain reaction

 

Surgical Pathology

Benign (%)

Malignant (%)

Total (%)

Cytology (Bethesday)

 I –Non- diagnostic

19 (20.7)

3 (3.2)

22 (23.9)

 II - Benign

30 (32.6)

4 (4.3)

34 (40.0)

 III – AUS/FLUS

7 (7.6)

4 (4.3)

11 (12.0)

 IV – FN/SFN

6 (6.5)

0

6 (6.5)

 V - SFM

0

4 (4.3)

4 (6.5)

 VI- Malignant

0

15 (16.3)

15 (16.3)

Mutations

 Low RNA

2 (2.2)

1 (1.1)

3 (3.2)

 HRASG12 V

14 (15.2)

6 (6.5)

20 (21.7)

 HRASQ61R

14 (15.2)

5 (5.4)

19 (20.7)

 HRASQ61K

8 (8.7)

1 (1.1)

9 (9.8)

 NRASQ61R

6 (6.5)

5 (5.4)

11 (12.0)

 NRASQ61K

3 (3.2)

0

3 (3.2)

 BRAFV600E

0

14 (15.2)

14 (15.2)

  1. Low RNA column indicates FNAB samples with RNA/nucleic acid < 1 ng, not used for ddPCR analysis
  2. AUS/FLUS atypia of uncertain significance/follicular lesion of undetermined significance, FN/SFN follicular neoplasm/suspicious for follicular neoplasm, SFM suspicious for malignancy