Skip to main content

Advertisement

Table 3 Distribution of pre-operative fine needle aspirate cytology and ddPCR mutation results in surgical specimen

From: Analytic and clinical validity of thyroid nodule mutational profiling using droplet digital polymerase chain reaction

  Surgical Pathology
Benign (%) Malignant (%) Total (%)
Cytology (Bethesday)
 I –Non- diagnostic 19 (20.7) 3 (3.2) 22 (23.9)
 II - Benign 30 (32.6) 4 (4.3) 34 (40.0)
 III – AUS/FLUS 7 (7.6) 4 (4.3) 11 (12.0)
 IV – FN/SFN 6 (6.5) 0 6 (6.5)
 V - SFM 0 4 (4.3) 4 (6.5)
 VI- Malignant 0 15 (16.3) 15 (16.3)
Mutations
 Low RNA 2 (2.2) 1 (1.1) 3 (3.2)
 HRASG12 V 14 (15.2) 6 (6.5) 20 (21.7)
 HRASQ61R 14 (15.2) 5 (5.4) 19 (20.7)
 HRASQ61K 8 (8.7) 1 (1.1) 9 (9.8)
 NRASQ61R 6 (6.5) 5 (5.4) 11 (12.0)
 NRASQ61K 3 (3.2) 0 3 (3.2)
 BRAFV600E 0 14 (15.2) 14 (15.2)
  1. Low RNA column indicates FNAB samples with RNA/nucleic acid < 1 ng, not used for ddPCR analysis
  2. AUS/FLUS atypia of uncertain significance/follicular lesion of undetermined significance, FN/SFN follicular neoplasm/suspicious for follicular neoplasm, SFM suspicious for malignancy