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Fig. 1 | Journal of Otolaryngology - Head & Neck Surgery

Fig. 1

From: The molecular mechanisms of increased radiosensitivity of HPV-positive oropharyngeal squamous cell carcinoma (OPSCC): an extensive review

Fig. 1

Cells have different radiosensitivities during different cell cycle phases. Cells during M phase have the highest sensitivity, as all chromosomes are condensed and packed in the middle of nucleus to form a bigger target, all the DNA repair mechanisms are shut down. On the contrary, all the chromosomes are very loose, and the DNA repair machineries are activated during S phase, so cells during S phase are most resistant to radiation. HPV+ OPSCC pass G1 and S phases quickly and accumulate at M Phase

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