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Fig. 4 | Journal of Otolaryngology - Head & Neck Surgery

Fig. 4

From: The molecular mechanisms of increased radiosensitivity of HPV-positive oropharyngeal squamous cell carcinoma (OPSCC): an extensive review

Fig. 4

Histological characteristics of HPV-positive and HPV-negative OPSCC. HPV-positive OPSCC normally shows no surface dysplasia or keratinization, it has lobular growth with infiltrating lymphocytes, and often demonstrates baseloid variation. Photo (a) is HPV− OPSCC, keratinizing tumor cells with abundant pink cytoplasm in discrete nests. Photo (b) shows HPV+ OPSCC, nonkeratinizing hyperchromatic tumor cells with ill-defined borders, abundant mitoses and areas of necrosis

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