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Table 1 Baseline Patient Characteristics

From: The role of induction chemotherapy followed by surgery in unresectable stage IVb laryngeal and hypopharyngeal cancers: a case series

Characteristics

Resectable qroup

N = 18 (%)

Unresectable group

N = 14 (%)

p-value

Age, year

 Mean (SD)

59.5 (3.13)

62.3 (3.29)

0.053

Sex

 Male

14 (77.8)

10 (71.4)

0.681

 Female

4 (22.2)

4 (28.6)

 

Performance status

 0

12 (66.7)

7 (50)

0.341

 1

6 (33.3)

7 (50)

 

Smoking

 Yes

12 (66.7)

10 (71.4)

0.773

 No

6 (33.3)

4 (28.6)

 

Alcohol

 Yes

8 (44.4)

8 (57.1)

0.476

 No

10 (55.6)

6 (42.9)

 

Primary site

 Larynx

9 (50)

3 (21.4)

0.098

 Hypopharynx

9 (50)

11 (78.6)

 

TN stage

 T3 N3

6 (33.3)

5 (35.7)

0.888

 T4bN2

5 (27.8)

4 (28.6)

 

 T4bN3

7 (38.9)

5 (35.7)

 

Causes of unresectability

 Preveterbral fascia invasion

4 (22.2)

5 (35.7)

0.960

 Carotid artery encasement

12 (66.7.)

5 (35.7)

 

 Preveterbral fascia invasion and carotid artery encasement

2 (11.1)

3 (21.4)

 

 Mediastinal structure involvement

0

1 (7.1)

 

Regimen

 TPF

11 (61.1)

3 (21.4)

0.080

 CP

3 (16.7)

5 (35.7)

 

 PF

4 (22.2)

6 (42.9)

 

Differentiation

 Poor

7 (38.9)

7 (50)

0.641

 Moderate

6 (33.3)

5 (35.7)

 

 Well

5 (27.8)

2 (14.3)

 
  1. TPF = docetaxel, cisplatin, and 5-fluorouracil, CP = carboplatin and paclitaxel, PF = cisplatin and 5-fluorouracil