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Table 2 Cox Proportional Hazard Model of Disease Specific Survival in Oropharyngeal Cancer Patients

From: EGFR as a biomarker of smoking status and survival in oropharyngeal squamous cell carcinoma

Covariate Univariate Multivariate
Hazard Ratio (95% CI) P Hazard Ratio (95% CI) P
Age 1.05 (1.03–1.08) < 0.001 1.04 (1.01–1.07) 0.01
Gender 1.41 (0.81–2.47) 0.22 1.14 (0.59–2.20) 0.69
P16 positive 0.30 (0.18–0.51) < 0.001 0.36 (0.19–0.68) 0.001
Smoking 10 py 2.73 (1.35–5.54) 0.005 1.90 (0.87–4.13) + EGFR
2.17 (1.06–4.46) - EGFR
0.1
0.003
Smoking 20 py 2.67 (1.58–4.52) < 0.001 1.52 (0.81–2.87) + EGFR
1.69 (0.97–2.95)- EGFR
0.2
0.06
EGFR total 2.28 (1.14–4.54) 0.02 1.51 (0.72–3.15) + smoking
1.96 (1.0–3.91) - smoking
0.28
0.05
TNM stage IV (vs III) 1.07 (0.61–1.89) 0.81 1.07 (0.56–2.04)  
  1. Multivariate models were generated using age as a continuous variable, and gender, smoking, p16 positivity, total EGFR levels and TNM stage as categorical covariates. Separate models were generated including: 1) all variables listed, 2) a model excluding smoking as shown for EGFR total and 3) models excluding EGFR for smoking status