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Table 2 Cox Proportional Hazard Model of Disease Specific Survival in Oropharyngeal Cancer Patients

From: EGFR as a biomarker of smoking status and survival in oropharyngeal squamous cell carcinoma

Covariate

Univariate

Multivariate

Hazard Ratio (95% CI)

P

Hazard Ratio (95% CI)

P

Age

1.05 (1.03–1.08)

< 0.001

1.04 (1.01–1.07)

0.01

Gender

1.41 (0.81–2.47)

0.22

1.14 (0.59–2.20)

0.69

P16 positive

0.30 (0.18–0.51)

< 0.001

0.36 (0.19–0.68)

0.001

Smoking 10 py

2.73 (1.35–5.54)

0.005

1.90 (0.87–4.13) + EGFR

2.17 (1.06–4.46) - EGFR

0.1

0.003

Smoking 20 py

2.67 (1.58–4.52)

< 0.001

1.52 (0.81–2.87) + EGFR

1.69 (0.97–2.95)- EGFR

0.2

0.06

EGFR total

2.28 (1.14–4.54)

0.02

1.51 (0.72–3.15) + smoking

1.96 (1.0–3.91) - smoking

0.28

0.05

TNM stage IV (vs III)

1.07 (0.61–1.89)

0.81

1.07 (0.56–2.04)

 
  1. Multivariate models were generated using age as a continuous variable, and gender, smoking, p16 positivity, total EGFR levels and TNM stage as categorical covariates. Separate models were generated including: 1) all variables listed, 2) a model excluding smoking as shown for EGFR total and 3) models excluding EGFR for smoking status
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Journal of Otolaryngology - Head & Neck Surgery

ISSN: 1916-0216

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