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Table 2 Risk distribution of local population compared to study population by stratification model

From: Risk stratification models in human papillomavirus-associated oropharyngeal squamous cell carcinoma: the Nova Scotia distribution

Model

Smoking History

Risk Level

Risk Description

Study Population

Model Population

Ang et al. 2010 [10]

HPV -ve: 73%

HPV +ve: 65%

Low Risk

10 PYHx

or

> 10 PYHx with N0-N2a

66.7%

64.0%

Intermediate Risk

> 10 PYHx with N2b-N3

33.3%

36.0%

O’Sullivan et al. 2013 [13]

HPV -ve: 94%

HPV +ve: 64%

Low risk

T1-T3, N0-N2c

87.2%

74.9%

High risk

T4,N0-N2c

or

N3

12.8%

25.1%

Huang et al. 2015 [12]

HPV -ve:

15 PYHx

HPV +ve:

40 PYHx

Low Risk

20 PYHx

62.4%

49.4%

Intermediate Risk

> 20 PYHx

or

Age 70

37.6%

45.9%

High Risk

Age > 70

0.0%

4.7%

Dahlstrom et al. 2016 [11]

HPV +ve: 82.5%

Low Risk

T1, N0-N2

24.8%

29.5%

Intermediate Risk

T2, N0-N2

or

T3

or

N3

64.1%

59.0%

High Risk

T4

11.1%

11.5%

  1. HPV + ve = p16 positive oropharyngeal squamous cell carcinoma, −ve = negative, PYHx = Pack Year History