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Table 2 Risk distribution of local population compared to study population by stratification model

From: Risk stratification models in human papillomavirus-associated oropharyngeal squamous cell carcinoma: the Nova Scotia distribution

Model Smoking History Risk Level Risk Description Study Population Model Population
Ang et al. 2010 [10] HPV -ve: 73%
HPV +ve: 65%
Low Risk 10 PYHx
or
> 10 PYHx with N0-N2a
66.7% 64.0%
Intermediate Risk > 10 PYHx with N2b-N3 33.3% 36.0%
O’Sullivan et al. 2013 [13] HPV -ve: 94%
HPV +ve: 64%
Low risk T1-T3, N0-N2c 87.2% 74.9%
High risk T4,N0-N2c
or
N3
12.8% 25.1%
Huang et al. 2015 [12] HPV -ve:
15 PYHx
HPV +ve:
40 PYHx
Low Risk 20 PYHx 62.4% 49.4%
Intermediate Risk > 20 PYHx
or
Age 70
37.6% 45.9%
High Risk Age > 70 0.0% 4.7%
Dahlstrom et al. 2016 [11] HPV +ve: 82.5% Low Risk T1, N0-N2 24.8% 29.5%
Intermediate Risk T2, N0-N2
or
T3
or
N3
64.1% 59.0%
High Risk T4 11.1% 11.5%
  1. HPV + ve = p16 positive oropharyngeal squamous cell carcinoma, −ve = negative, PYHx = Pack Year History