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Table 1 Characteristics of the included studies

From: Systematic review and meta-analysis of T1 glottic cancer outcomes comparing CO2 transoral laser microsurgery and radiotherapy

Study Year Country Design Study Period Cancer Staging Arms Stages Sample Size Sex (M:F) Mean Age (range) Selection Bias ELS Type Quality Score
Low et al. [11] 2017 Canada retro 2003–2013 NR TLM, RT T1a 105 86:19 68 NR NR Level III
Alkan et al. [12] 2017 Israel retro 2006–2013 NR TLM, RT T1a T1b 23 31 46:8 68 (36–95) AC, Age, Tumor IV / V Level III
Taylor et al. [13] 2013 Canada pro 2002–2010 NR TLM, RT T1b 63 57:6 67 NR NR Level II
Remmelts et al. [14] 2013 Netherlands retro 2000–2008 200;2 UICC TLM, RT Tis T1a T1b T2 26 103 42 77 88:12 65 (39–89) NR NR Level III
Kerr et al. [15] 2012 Canada retro 2002–2010 NR TLM, RT T1a T1b T2 146 41 46 205:29 67 NR NR Level III
Kujath et al. [20] 2011 Canada retro 2000–2009 NR TLM, RT T1 T2 64 15 69:10 NR Time Period NR Level III
Mahler et al. [25] 2010 Norway pro 1986–2005 2002 UICC TLM, RT T1a 351 318:33 66 (31–90) Time period NR Level II
Schrijvers et al. [26] 2009 Netherlands retro 1990–2004 2002 AJCC TLM, RT T1a 100 88:12 66 (38–83) Time period I / II Level III
Thurnher et al. [28] 2008 Austria retro 1948–1997 2002 UICC TLM, RT, PL T1a 337 309:28 63 (28–90) NR NR Level III
Sjögren et al. [23] 2008 Netherlands retro 1996–2007 NR TLM, RT T1a 181 165:15 70 (33–95) AC I / II Level III
Goor et al. [22] 2007 Netherlands retro 1995–1999 NR TLM, RT T1a 89 85:4 65 (42–83) Tumor (Depth) II Level III
Krengli et al. [18] 2004 Italy retro 1990–2001 NR TLM, RT T1a 57 55:2 68 (55–81) NR III / IV Level III
Stoeckli et al. [19] 2003 Switzerland retro 1990–1998 1997 UICC TLM, RT T1 T2 101 39 132:8 63 (41–88) Stage, Tumor NR Level III
Brandenburg [21] 2001 USA retro 1989–1999 NR TLM, RT T1a T1b 70 4 65:9 64 (33–88) AC NR Level III
Rosier et al. [24] 1998 Belgium retro 1979–1995 1987 UICC TLM, RT, PL T1a T1b 81 25 93:13 64 (43–88) Age, AC, Stage NR Level III
Epstein et al. [27] 1990 USA retro 1975–1987 1988 AJCC TLM, RT T1a 77 71:6 63 NR NR Level III
  1. Abbreviations: AC anterior commissure, AJCC American joint committee on cancer, ELS European laryngological society, F/U follow-up, NR not reported, PL partial laryngectomy, pro prospective, RT radiotherapy, retro retrospective, TLM transoral laser microsurgery, UICC Union for international cancer control