Table 1 Characteristics of the included studies
Study | Year | Country | Design | Study Period | Cancer Staging | Arms | Stages | Sample Size | Sex (M:F) | Mean Age (range) | Selection Bias | ELS Type | Quality Score |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Low et al. [11] | 2017 | Canada | retro | 2003–2013 | NR | TLM, RT | T1a | 105 | 86:19 | 68 | NR | NR | Level III |
Alkan et al. [12] | 2017 | Israel | retro | 2006–2013 | NR | TLM, RT | T1a T1b | 23 31 | 46:8 | 68 (36–95) | AC, Age, Tumor | IV / V | Level III |
Taylor et al. [13] | 2013 | Canada | pro | 2002–2010 | NR | TLM, RT | T1b | 63 | 57:6 | 67 | NR | NR | Level II |
Remmelts et al. [14] | 2013 | Netherlands | retro | 2000–2008 | 200;2 UICC | TLM, RT | Tis T1a T1b T2 | 26 103 42 77 | 88:12 | 65 (39–89) | NR | NR | Level III |
Kerr et al. [15] | 2012 | Canada | retro | 2002–2010 | NR | TLM, RT | T1a T1b T2 | 146 41 46 | 205:29 | 67 | NR | NR | Level III |
Kujath et al. [20] | 2011 | Canada | retro | 2000–2009 | NR | TLM, RT | T1 T2 | 64 15 | 69:10 | NR | Time Period | NR | Level III |
Mahler et al. [25] | 2010 | Norway | pro | 1986–2005 | 2002 UICC | TLM, RT | T1a | 351 | 318:33 | 66 (31–90) | Time period | NR | Level II |
Schrijvers et al. [26] | 2009 | Netherlands | retro | 1990–2004 | 2002 AJCC | TLM, RT | T1a | 100 | 88:12 | 66 (38–83) | Time period | I / II | Level III |
Thurnher et al. [28] | 2008 | Austria | retro | 1948–1997 | 2002 UICC | TLM, RT, PL | T1a | 337 | 309:28 | 63 (28–90) | NR | NR | Level III |
Sjögren et al. [23] | 2008 | Netherlands | retro | 1996–2007 | NR | TLM, RT | T1a | 181 | 165:15 | 70 (33–95) | AC | I / II | Level III |
Goor et al. [22] | 2007 | Netherlands | retro | 1995–1999 | NR | TLM, RT | T1a | 89 | 85:4 | 65 (42–83) | Tumor (Depth) | II | Level III |
Krengli et al. [18] | 2004 | Italy | retro | 1990–2001 | NR | TLM, RT | T1a | 57 | 55:2 | 68 (55–81) | NR | III / IV | Level III |
Stoeckli et al. [19] | 2003 | Switzerland | retro | 1990–1998 | 1997 UICC | TLM, RT | T1 T2 | 101 39 | 132:8 | 63 (41–88) | Stage, Tumor | NR | Level III |
Brandenburg [21] | 2001 | USA | retro | 1989–1999 | NR | TLM, RT | T1a T1b | 70 4 | 65:9 | 64 (33–88) | AC | NR | Level III |
Rosier et al. [24] | 1998 | Belgium | retro | 1979–1995 | 1987 UICC | TLM, RT, PL | T1a T1b | 81 25 | 93:13 | 64 (43–88) | Age, AC, Stage | NR | Level III |
Epstein et al. [27] | 1990 | USA | retro | 1975–1987 | 1988 AJCC | TLM, RT | T1a | 77 | 71:6 | 63 | NR | NR | Level III |