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Table 3 Relationships between genotypes of IL-1 receptor genetic polymorphisms and age-related hearing impairment

From: The association of genetic polymorphisms in interleukin-1 receptors type 1 and type 2 with age-related hearing impairment in a Taiwanese population: a case control study

Gene

SNP

Model

Genotype

ARHI

Control

Crude

Adjusteda

OR (95% CI)

p

OR (95% CI)

p

IL1R1

rs3917225

Codominant

AA

66 (38.6%)

53 (32.5%)

1.000

 

1.000

 

AG

84 (49.1%)

80 (49.1%)

0.843 (0.525–1.354)

0.480

0.637 (0.329–1.232)

0.180

GG

21 (12.3%)

30 (18.4%)

0.562 (0.289–1.093)

0.089

0.374 (0.146–0.956)

0.040*

Dominant

AA

66 (38.6%)

53 (32.5%)

1.000

 

1.000

 

AG + GG

105 (61.4%)

110 (67.5%)

0.767 (0.489–1.202)

0.246

0.546 (0.301–0.991)

0.047*

Recessive

AA+AG

150 (87.7%)

133 (81.6%)

1.000

 

1.000

 

GG

21 (12.3%)

30 (18.4%)

0.621 (0.339–1.136)

0.122

0.420 (0.182–1.966)

0.041*

rs2234650

Codominant

CC

100 (55.9%)

91 (52.9%)

1.000

 

1.000

 

CT

70 (39.1%)

73 (42.4%)

0.882 (0.565–1.378)

0.583

0.982 (0.542–1.780)

0.952

TT

9 (5.0%)

8 (4.7%)

0.511 (0.149–1.758)

0.287

0.526 (0.127–2.171)

0.374

Dominant

CC

100 (55.9%)

91 (52.9%)

1.000

 

1.000

 

CT + TT

79 (44.1%)

81 (47.1%)

0.888 (0.583–1.351)

0.578

1.012 (0.582–1.759)

0.966

Recessive

CC + CT

170 (95.0%)

164 (95.3%)

1.000

 

1.000

 

TT

9 (5.0%)

8 (4.7%)

1.085 (0.409–2.881)

0.869

1.098 (0.348–3.463)

0.873

IL1R2

rs4141134

Codominant

TT

165 (92.7%)

160 (92.5%)

1.000

 

1.000

 

TC

13 (7.3%)

13 (7.5%)

0.940 (0.408–2.165)

0.885

0.500 (0.163–1.535)

0.226

CC

0 (0)

0 (0)

NA

NA

NA

NA

Dominant

TT

165 (92.7%)

160 (92.5%)

1.000

 

1.000

 

TC + CC

13 (7.3%)

13 (7.5%)

0.940 (0.408–2.165)

0.885

0.500 (0.163–1.535)

0.226

Recessive

TT + TC

178 (100%)

173 (100%)

1.000

 

1.000

 

CC

0 (0)

0 (0)

NA

NA

NA

NA

rs2071008

Codominant

GG

104 (59.1%)

104 (63.4%)

1.000

 

1.000

 

GT

68 (38.6%)

53 (32.3%)

1.224 (0.768–1.950))

0.395

1.416 (0.769–2.609)

0.264

TT

4 (2.3%)

7 (4.3%)

0.479 (0.120–1.907)

0.297

0.190 (0.032–1.110)

0.065

Dominant

GG

104 (59.1%)

104 (63.4%)

1.000

 

1.000

 

GT + TT

72 (40.9%)

60 (36.6%)

1.200 (0.775–1.858)

0.414

1.294 (0.736–2.227)

0.370

Recessive

GG + GT

172 (97.7%)

157 (95.7%)

1.000

 

1.000

 

TT

4 (2.3%)

7 (4.3%)

0.522 (0.150–1.816)

0.306

0.187 (0.037–0.944)

0.042*

  1. a: Logistic regression; adjusted for age, sex and noise exposure
  2. *: p < 0.05