Gene | SNP | Model | Genotype | ARHI | Control | Crude | Adjusteda | ||
---|---|---|---|---|---|---|---|---|---|
OR (95% CI) | p | OR (95% CI) | p | ||||||
IL1R1 | rs3917225 | Codominant | AA | 66 (38.6%) | 53 (32.5%) | 1.000 | 1.000 | ||
AG | 84 (49.1%) | 80 (49.1%) | 0.843 (0.525–1.354) | 0.480 | 0.637 (0.329–1.232) | 0.180 | |||
GG | 21 (12.3%) | 30 (18.4%) | 0.562 (0.289–1.093) | 0.089 | 0.374 (0.146–0.956) | 0.040* | |||
Dominant | AA | 66 (38.6%) | 53 (32.5%) | 1.000 | 1.000 | ||||
AG + GG | 105 (61.4%) | 110 (67.5%) | 0.767 (0.489–1.202) | 0.246 | 0.546 (0.301–0.991) | 0.047* | |||
Recessive | AA+AG | 150 (87.7%) | 133 (81.6%) | 1.000 | 1.000 | ||||
GG | 21 (12.3%) | 30 (18.4%) | 0.621 (0.339–1.136) | 0.122 | 0.420 (0.182–1.966) | 0.041* | |||
rs2234650 | Codominant | CC | 100 (55.9%) | 91 (52.9%) | 1.000 | 1.000 | |||
CT | 70 (39.1%) | 73 (42.4%) | 0.882 (0.565–1.378) | 0.583 | 0.982 (0.542–1.780) | 0.952 | |||
TT | 9 (5.0%) | 8 (4.7%) | 0.511 (0.149–1.758) | 0.287 | 0.526 (0.127–2.171) | 0.374 | |||
Dominant | CC | 100 (55.9%) | 91 (52.9%) | 1.000 | 1.000 | ||||
CT + TT | 79 (44.1%) | 81 (47.1%) | 0.888 (0.583–1.351) | 0.578 | 1.012 (0.582–1.759) | 0.966 | |||
Recessive | CC + CT | 170 (95.0%) | 164 (95.3%) | 1.000 | 1.000 | ||||
TT | 9 (5.0%) | 8 (4.7%) | 1.085 (0.409–2.881) | 0.869 | 1.098 (0.348–3.463) | 0.873 | |||
IL1R2 | rs4141134 | Codominant | TT | 165 (92.7%) | 160 (92.5%) | 1.000 | 1.000 | ||
TC | 13 (7.3%) | 13 (7.5%) | 0.940 (0.408–2.165) | 0.885 | 0.500 (0.163–1.535) | 0.226 | |||
CC | 0 (0) | 0 (0) | NA | NA | NA | NA | |||
Dominant | TT | 165 (92.7%) | 160 (92.5%) | 1.000 | 1.000 | ||||
TC + CC | 13 (7.3%) | 13 (7.5%) | 0.940 (0.408–2.165) | 0.885 | 0.500 (0.163–1.535) | 0.226 | |||
Recessive | TT + TC | 178 (100%) | 173 (100%) | 1.000 | 1.000 | ||||
CC | 0 (0) | 0 (0) | NA | NA | NA | NA | |||
rs2071008 | Codominant | GG | 104 (59.1%) | 104 (63.4%) | 1.000 | 1.000 | |||
GT | 68 (38.6%) | 53 (32.3%) | 1.224 (0.768–1.950)) | 0.395 | 1.416 (0.769–2.609) | 0.264 | |||
TT | 4 (2.3%) | 7 (4.3%) | 0.479 (0.120–1.907) | 0.297 | 0.190 (0.032–1.110) | 0.065 | |||
Dominant | GG | 104 (59.1%) | 104 (63.4%) | 1.000 | 1.000 | ||||
GT + TT | 72 (40.9%) | 60 (36.6%) | 1.200 (0.775–1.858) | 0.414 | 1.294 (0.736–2.227) | 0.370 | |||
Recessive | GG + GT | 172 (97.7%) | 157 (95.7%) | 1.000 | 1.000 | ||||
TT | 4 (2.3%) | 7 (4.3%) | 0.522 (0.150–1.816) | 0.306 | 0.187 (0.037–0.944) | 0.042* |