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Table 3 Relationships between genotypes of IL-1 receptor genetic polymorphisms and age-related hearing impairment

From: The association of genetic polymorphisms in interleukin-1 receptors type 1 and type 2 with age-related hearing impairment in a Taiwanese population: a case control study

GeneSNPModelGenotypeARHIControlCrudeAdjusteda
OR (95% CI)pOR (95% CI)p
IL1R1rs3917225CodominantAA66 (38.6%)53 (32.5%)1.000 1.000 
AG84 (49.1%)80 (49.1%)0.843 (0.525–1.354)0.4800.637 (0.329–1.232)0.180
GG21 (12.3%)30 (18.4%)0.562 (0.289–1.093)0.0890.374 (0.146–0.956)0.040*
DominantAA66 (38.6%)53 (32.5%)1.000 1.000 
AG + GG105 (61.4%)110 (67.5%)0.767 (0.489–1.202)0.2460.546 (0.301–0.991)0.047*
RecessiveAA+AG150 (87.7%)133 (81.6%)1.000 1.000 
GG21 (12.3%)30 (18.4%)0.621 (0.339–1.136)0.1220.420 (0.182–1.966)0.041*
rs2234650CodominantCC100 (55.9%)91 (52.9%)1.000 1.000 
CT70 (39.1%)73 (42.4%)0.882 (0.565–1.378)0.5830.982 (0.542–1.780)0.952
TT9 (5.0%)8 (4.7%)0.511 (0.149–1.758)0.2870.526 (0.127–2.171)0.374
DominantCC100 (55.9%)91 (52.9%)1.000 1.000 
CT + TT79 (44.1%)81 (47.1%)0.888 (0.583–1.351)0.5781.012 (0.582–1.759)0.966
RecessiveCC + CT170 (95.0%)164 (95.3%)1.000 1.000 
TT9 (5.0%)8 (4.7%)1.085 (0.409–2.881)0.8691.098 (0.348–3.463)0.873
IL1R2rs4141134CodominantTT165 (92.7%)160 (92.5%)1.000 1.000 
TC13 (7.3%)13 (7.5%)0.940 (0.408–2.165)0.8850.500 (0.163–1.535)0.226
CC0 (0)0 (0)NANANANA
DominantTT165 (92.7%)160 (92.5%)1.000 1.000 
TC + CC13 (7.3%)13 (7.5%)0.940 (0.408–2.165)0.8850.500 (0.163–1.535)0.226
RecessiveTT + TC178 (100%)173 (100%)1.000 1.000 
CC0 (0)0 (0)NANANANA
rs2071008CodominantGG104 (59.1%)104 (63.4%)1.000 1.000 
GT68 (38.6%)53 (32.3%)1.224 (0.768–1.950))0.3951.416 (0.769–2.609)0.264
TT4 (2.3%)7 (4.3%)0.479 (0.120–1.907)0.2970.190 (0.032–1.110)0.065
DominantGG104 (59.1%)104 (63.4%)1.000 1.000 
GT + TT72 (40.9%)60 (36.6%)1.200 (0.775–1.858)0.4141.294 (0.736–2.227)0.370
RecessiveGG + GT172 (97.7%)157 (95.7%)1.000 1.000 
TT4 (2.3%)7 (4.3%)0.522 (0.150–1.816)0.3060.187 (0.037–0.944)0.042*
  1. a: Logistic regression; adjusted for age, sex and noise exposure
  2. *: p < 0.05