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Table 1 Surveillance options for IP malignant transformation

From: Clinical evidence based review and systematic scientific review in the identification of malignant transformation of inverted papilloma

Clinical investigation options

Endoscopy

Computed Tomography

Magnetic Resonance Imaging

PET-CT with FDG

Biologic markers

Genetic factors (P53, P21, MSX2, PDCD4, KRAS, PTEN)

Proteins (SCCa, fascin, surviving, COX-2, cell adhesion molecules, Ki-67 etc)

Viral (HPV, EBV)