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Table 4 Follow up duration of IP malignant transformation surveillance

From: Clinical evidence based review and systematic scientific review in the identification of malignant transformation of inverted papilloma

Study authorsYearStudy designLevel of evidenceStudy groupsInterventionOutcomeConclusion
Lin et al. [14]2014Observational studyC129 patients, 19 SCC (14.7%)Medical history reviewed.IP requires follow up of more than 2 years. 5 year survival for IP with SCC is 61%. No clear predictors of malignancy were seen in this study.Smoking significantly affected overall survival by impacting carcinomatous progression. The most common lesion location was the medial maxillary sinus, maxillary sinus and ethmoid sinus. The mean interval between initial resection and diagnosis of malignancy was 73 months.
Liang et al. [10]2015Observational studyC213 patients, 87 SCC.Medical history reviewed.Age, synchronous or metachronous tumors, and pathological stage were independent risk factors for mortality.Factors associated with significantly poor prognosis were: advanced-stage, metachronous tumors, and cranial base or orbit invasion. Mean follow up time was 40 months.
Nudell et al. [3]2014Observational studyC20 IP-SCCMedical history reviewedAn average of 34.4 months between first diagnosis of SP to IP-SCC identified.SP that may undergo malignant transformation are nearly impossible to identify based on morphologic examination.