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Table 1 Main characteristics of the eligible studies

From: Prognostic value of lymph node ratio in laryngeal and hypopharyngeal squamous cell carcinoma: a systematic review and meta-analysis

Study Year Region Study period Type of study Population Endpoints with HR LNR cut-off Method of LNR determination Follow-up time (months)
Ye [22] 2018 China 2007 to 2016 retrospective HPSCC OS, DFS <0.07,≥0.07 ROC Median 33.1
(6.1 to 110.7)
Lo [15] 2017 Taipei, China 2001 to 2007 retrospective HPSCC OS, DFS, DSS < 0.113, ≥0.113 Mean Mean 51
(4 to 144)
Suzuki [21] 2016 Japan 2000 to 2015 prospective HPSCC OS, DFS < 0.09, ≥0.09 Log-rank test Mean ± SD
45.7 ± 40.6
Joo [14] 2015 Korea 1993 to 2014 retrospective HPSCC OS, DFS < 0.055, ≥0.055 ROC Mean 37
(1 to 151)
Hua [13] 2015 China 2000 to 2005 retrospective HPSCC OS < 10, > 10% NA Median 48
(12 to 127)
Yu [29] 2013 China 1965 to 2008 retrospective HPSCC OS, DFS, DSS ≤0.14, > 0.14 LNR quartiles Mean 41.8
(1 to 295)
Wang [27] 2013 SEER 1988 to 2008 retrospective HPSCC OS, DFS 0–0.05, 0.05–0.30, > 0.30 Log-rank test Median 23
(0 to 238)
Imre [19] 2016 Turkey 2006 to 2014 retrospective LSCC OS, DFS < 0.09, ≥0.09 Univariate Cox analysis Mean 33.5
(6 to 94)
Ryu [16] 2015 Korea 2001 to 2010 retrospective LSCC DFS ≤0.044, > 0.044 ROC Median 53.2
(2.1 to 147.1)
Wang [28] 2014 SEER 1988 to 2008 retrospective LSCC OS, DFS 0–0.09, 0.09–0.20, > 0.20 Log-rank test NA
Künzel [20] 2015 Germany 1980 to 2010 retrospective LSCC DFS < 0.09, > 0.09/< 0.09, > 0.09 ROC Mean 53
(0.1 to 229)
Choi [12] 2019 Germany 2006 to 2016 retrospective HPSCC/LSCC OS, DFS, DSS 0.03 ROC Median 60
(24 to 134)
Grasl [18] 2019 Austria 1994 to 2018 retrospective HPSCC/LSCC OS, DFS, DSS ≤0.07, > 0.07 ROC Mean ± SD
55.6 ± 59.3
  1. HPSCC hypopharyngeal squamous cell carcinoma, LSCC laryngeal squamous cell carcinoma, OS overall survival, DSS disease-specific survival, DFS disease-free survival, ROC receiver operating characteristic; NA: not available