Fig. 2

ABR thresholds by day across the four frequencies (3 K, 6 k, 12 k and 24 K Hz) tested. Day 0 is the initial day. Day 30 represents the thresholds after CDDP administration but before BDNF/saline administration and day 60 represents the thresholds after BDNF or saline administration. Although the thresholds are greater at day 60 they do not differ significantly by frequency (p = 0.088). thresholds differ between day 30 and day 60 in both groups. This difference in the saline group probably represents the hearing loss induced by the intracochlear injection procedure alone (21 dB) which is of concern if these methods were to be applied to humans