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Table 1 Descriptive diagnosis of acute exacerbations in adult patients with CRS

From: Definition and characteristics of acute exacerbation in adult patients with chronic rhinosinusitis: a systematic review

Author/year Definition of an acute exacerbation in CRS
Zemke, et al. (2019) [13] The presence of increased nasal congestion, and facial pain; increased sinonasal discharge; usually presence of an unscheduled sick visit.
Orlandi, RR, et al. (2018) [8] AE in CRS is defined in a patient in whom a previous diagnosis of CRS exists, and a sudden worsening of symptoms occurs, with a return to baseline symptoms following treatment.
Divekar, et al. (2015) [14] A natural exacerbation was defined as patient-reported worsening of sinonasal symptoms (i.e. runny nose, nasal congestion, and nasal obstruction).
Fokkens, et al. (2012) [7] A history of sudden worsening of preexisting symptoms suggests an acute exacerbation of chronic rhinosinusitis, which should be diagnosed by similar criteria and treated in a similar way to ARS.
Kuiper, et al. (2018) [15] Self-reported medication use (antibiotics and oral corticosteroids) for worsened nasal and sinus symptoms; self-reported worsened purulence in the past 4 weeks.
Rank, et al. (2010) [16] Systemic antibiotics; systemic corticosteroid; plans for a semi-urgent surgical intervention; emergency department or urgent care visit, or a hospitalization for CRS.
Reh, et al. (2009) [17] Worse nasal symptoms
  1. CRS Chronic rhinosinusitis, CF Cystic fibrosis, AE Acute exacerbation, ICAR: RS International Consensus Statement on Allergy and Rhinology: Rhinosinusitis, EPOS European position paper on rhinosinusitis and nasal polyps, ARS Acute rhinosinusitis