Table 2 Major aetiology of Oral Submucous Fibrosis
Major aetiology | Description |
|---|---|
Chewing of Areca nut (Baked or Raw) and/or derivatives such as Gutkha, Pan masala, Mawa, Betel quid, Sweet Supari and other formulations. | Arecoline and Arecaidine nitrosation causes DNA alkylation with proliferation of fibroblasts and elevated collagen synthesis [39]. |