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Table 1 Clinical characteristics in patients with high vs. low LncRNA scores

From: Role of LncRNA score and PVT1 in primary hyperparathyroidism-- a preliminary study

Clinical characteristics Patients with Low lncRNA score (n = 29) Patients with High lncRNA score (n = 28) P-value
Age (SD)(years) 56.5 (14.5) 60.1 (11.1) 0.286
Sex (% M) 24.1 46.4 0.068
Disease course (SD) (month) 67.0 (97.5) 74.0 (90.96) 0.784
Cause of first diagnosis (%) With any discomfort 51.7 75.0 0.100
  discomfort in Bone system 31.0 35.7 0.783
  Nephrolith 17.2 14.3 0.100
  Discomfort in Digestive system 3.5 10.7 0.352
  Thyroid nodular 10.3 14.3 0.706
  Elevated Ca2+ level 27.6 21.4 0.760
Clinical manifestation (%) Bone system 72.4 60.7 0.408
  Nephrolith 55.2 25.0 0.031
  Digestive system 24.1 32.1 0.565
Laboratory examination iPTH (SD) (pg/mL) 604.6 (624.2) 544.9 (592.3) 0.713
  Ca2+(SD) (mmol/L) 2.75 (0.32) 2.98 (0.42) 0.028*
  Albumin adjusted Ca2+(SD)(mmol/L) 2.73 (0.32) 2.98 (0.45) 0.020*
  P (SD)(mmol/L) 0.79 (0.25) 0.89 (0.49) 0.363
  ALP (SD) (U/L) 236.8 (359.0) 121.9 (52.0) 0.099
Imaging location consistent with histopathology (%, n) Tc-99 m-MIBI 81.0 (n = 21) 86.7 (n = 15) 1.000
  Contrast enhanced CT 53.3 (n = 15) 88.9 (n = 9) 0.073
  Thyroid ultrasound 75.0 (n = 24) 66.7 (n = 8) 0.440
Histopathology Maximum diameter (SD) (cm) 2.10 (2.31) 2.48 (1.31) 0.271
  parathyroid cancer (%, n) 6.9 32.1 0.021#
lncRNA PVT1 (SD) 0.32 (0.44) 2.72 (4.89) 0.015*
  1. iPTH Intact parathyroid hormone, Ca Serum total calcium, P Serum phosphorus, ALP Alkaline phosphatase, SPECT Single photon emission computed tomography, Tc-99 m-MIBI Technetium-99 m methoxyisobutylisonitrate, CT Computed tomography, MRI Magnetic resonance. *P < 0.05 for Independent Student’s t-test; #P < 0.05 forχ2 test