Table 2 Relationships between alleles of HSP70 genetic polymorphisms and age-related hearing impairment
Gene | SNP | Allele | ARHI | Control | Crude | Adjusteda | ||
|---|---|---|---|---|---|---|---|---|
OR (95% CI) | p | OR (95% CI) | p | |||||
HSPA1A | rs1043618 | G | 202 (71.1%) | 209 (73.1%) | 1.000 | 1.000 | ||
C | 82 (28.9%) | 77 (26.9%) | 1.102 (0.764–1.589) | 0.604 | 1.111 (0.763–1.618) | 0.583 | ||
HSPA1L | rs2227956 | A | 227 (79.4%) | 241 (83.1%) | 1.000 | 1.000 | ||
G | 59 (20.6%) | 49 (16.9%) | 1.278 (0.840–1.946) | 0.252 | 1.333 (0.863–2.508) | 0.195 | ||
rs2075800 | C | 176 (60.7%) | 181 (62.8%) | 1.000 | 1.000 | |||
T | 114 (39.3%) | 107 (37.2%) | 1.096 (0.783–1.533) | 0.594 | 1.033 (0.730–1.461) | 0.854 | ||
HSPA1B | rs2763979 | C | 214 (74.8%) | 171 (60.6%) | 1.000 | 1.000 | ||
T | 72 (25.2%) | 112 (39.4%) | 0.517 (0.361–0.739) | < 0.001** | 0.520 (0.360–0.751) | < 0.001** | ||