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Table 3 Relationships between genotypes of HSP70 genetic polymorphisms and age-related hearing impairment

From: The association of heat shock protein genetic polymorphisms with age-related hearing impairment in Taiwan

Gene SNP Model Genotype ARHI Control Crude Adjusteda
OR (95% CI) p OR (95% CI) p
HSPA1A rs1043618 Additive GG 71 (50.0%) 76 (53.1%) 1.000   1.000  
    CG 60 (42.3%) 57 (39.9%) 1.127 (0.693–1.832) 0.630 1.185 (0.718–1.956) 0.506
    CC 11 (7.7%) 10 (7.0%) 1.177 (0.471–2.941) 0.727 1.116 (0.435–2.862) 0.819
   Dominant GG 71 (50.0%) 76 (53.1%) 1.000    
    CC + CG 71 (50.0%) 67 (46.9%) 1.134 (0.713–1.806) 0.595 1.175 (0.728–1.896) 0.510
   Recessive GG + CG 131 (93.0%) 133 (92.3%) 1.000   1.000  
    CC 11 (7.0%) 10 (7.7%) 1.117 (0.459–2.719) 0.808 1.036 (0.415–2.584) 0.940
HSPA1L rs2227956 Additive AA 89 (62.2%) 99 (68.3%) 1.000   1.000  
    AG 49 (43.3%) 43 (29.7%) 1.268 (0.769–2.089) 0.352 1.350 (0.805–2.264) 0.255
    GG 5 (3.5%) 3 (2.1%) 1.854 (0.431–7.981) 0.407 1.857 (0.411–8.389) 0.421
   Dominant AA 89 (62.2%) 99 (68.3%) 1.000   1.000  
    AG + GG 54 (37.8%) 46 (31.7%) 1.306 (0.803–2.124) 0.282 1.384 (0.837–2.290) 0.205
   Recessive AA+AG 138 (96.5%) 142 (97.9%) 1.000   1.000  
    GG 5 (3.5%) 3 (2.1%) 1.715 (0.402–7.314) 0.466 1.683 (0.377–7.526) 0.495
  rs2075800 Additive CC 48 (33.1%) 60 (41.7%) 1.000   1.000  
    CT 80 (55.2%) 61 (42.4%) 1.639 (0.989–2.2.716) 0.055 1.572 (0.933–2.648) 0.089
    TT 17 (11.7%) 23 (16.0%) 0.924 (0.444–1.923) 0.832 0.812 (0.382–1.727) 0.588
   Dominant CC 48 (33.1%) 60 (41.7%) 1.000   1.000  
    CT + TT 97 (66.9%) 84 (58.3%) 1.443 (0.894–2.330) 0.133 1.357 (0.828–2.224) 0.226
   Recessive CC + CT 128 (88.3%) 121 (84.0%) 1.000   1.000  
    TT 17 (11.7%) 23 (16.0%) 0.699 (0.356–1.371) 0.297 0.627 (0.313–1.256) 0.188
HSPA1B rs2763979 Additive CC 82 (57.3%) 50 (35.2%) 1.000   1.000  
    CT 50 (35.0%) 72 (50.7%) 0.423 (0.256–0.701) 0.001** 0.425 (0.253–0.714) 0.001**
    TT 11 (7.7%) 20 (14.1%) 0.335 (0.148–0.758) 0.009* 0.337 (0.146–0.779) 0.011*
   Dominant CC 82 (57.3%) 50 (35.2%) 1.000   1.000  
    CT + TT 61 (42.7%) 92 (64.8%) 0.404 (0.251–0.652) < 0.001** 0.406 (0.248–0.664) < 0.001**
   Recessive CC + CT 132 (92.3%) 122 (85.9%) 1.000   1.000  
    TT 11 (7.7%) 20 (14.1%) 0.508 (0.234–1.104) 0.087 0.512 (0.231–1.136) 0.100
  1. a: adjusted for sex and noise exposure
  2. *: p < 0.05
  3. **: p < 0.001
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Journal of Otolaryngology - Head & Neck Surgery

ISSN: 1916-0216

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