Table 3 Relationships between genotypes of HSP70 genetic polymorphisms and age-related hearing impairment
Gene | SNP | Model | Genotype | ARHI | Control | Crude | Adjusteda | ||
|---|---|---|---|---|---|---|---|---|---|
OR (95% CI) | p | OR (95% CI) | p | ||||||
HSPA1A | rs1043618 | Additive | GG | 71 (50.0%) | 76 (53.1%) | 1.000 | 1.000 | ||
CG | 60 (42.3%) | 57 (39.9%) | 1.127 (0.693–1.832) | 0.630 | 1.185 (0.718–1.956) | 0.506 | |||
CC | 11 (7.7%) | 10 (7.0%) | 1.177 (0.471–2.941) | 0.727 | 1.116 (0.435–2.862) | 0.819 | |||
Dominant | GG | 71 (50.0%) | 76 (53.1%) | 1.000 | |||||
CC + CG | 71 (50.0%) | 67 (46.9%) | 1.134 (0.713–1.806) | 0.595 | 1.175 (0.728–1.896) | 0.510 | |||
Recessive | GG + CG | 131 (93.0%) | 133 (92.3%) | 1.000 | 1.000 | ||||
CC | 11 (7.0%) | 10 (7.7%) | 1.117 (0.459–2.719) | 0.808 | 1.036 (0.415–2.584) | 0.940 | |||
HSPA1L | rs2227956 | Additive | AA | 89 (62.2%) | 99 (68.3%) | 1.000 | 1.000 | ||
AG | 49 (43.3%) | 43 (29.7%) | 1.268 (0.769–2.089) | 0.352 | 1.350 (0.805–2.264) | 0.255 | |||
GG | 5 (3.5%) | 3 (2.1%) | 1.854 (0.431–7.981) | 0.407 | 1.857 (0.411–8.389) | 0.421 | |||
Dominant | AA | 89 (62.2%) | 99 (68.3%) | 1.000 | 1.000 | ||||
AG + GG | 54 (37.8%) | 46 (31.7%) | 1.306 (0.803–2.124) | 0.282 | 1.384 (0.837–2.290) | 0.205 | |||
Recessive | AA+AG | 138 (96.5%) | 142 (97.9%) | 1.000 | 1.000 | ||||
GG | 5 (3.5%) | 3 (2.1%) | 1.715 (0.402–7.314) | 0.466 | 1.683 (0.377–7.526) | 0.495 | |||
rs2075800 | Additive | CC | 48 (33.1%) | 60 (41.7%) | 1.000 | 1.000 | |||
CT | 80 (55.2%) | 61 (42.4%) | 1.639 (0.989–2.2.716) | 0.055 | 1.572 (0.933–2.648) | 0.089 | |||
TT | 17 (11.7%) | 23 (16.0%) | 0.924 (0.444–1.923) | 0.832 | 0.812 (0.382–1.727) | 0.588 | |||
Dominant | CC | 48 (33.1%) | 60 (41.7%) | 1.000 | 1.000 | ||||
CT + TT | 97 (66.9%) | 84 (58.3%) | 1.443 (0.894–2.330) | 0.133 | 1.357 (0.828–2.224) | 0.226 | |||
Recessive | CC + CT | 128 (88.3%) | 121 (84.0%) | 1.000 | 1.000 | ||||
TT | 17 (11.7%) | 23 (16.0%) | 0.699 (0.356–1.371) | 0.297 | 0.627 (0.313–1.256) | 0.188 | |||
HSPA1B | rs2763979 | Additive | CC | 82 (57.3%) | 50 (35.2%) | 1.000 | 1.000 | ||
CT | 50 (35.0%) | 72 (50.7%) | 0.423 (0.256–0.701) | 0.001** | 0.425 (0.253–0.714) | 0.001** | |||
TT | 11 (7.7%) | 20 (14.1%) | 0.335 (0.148–0.758) | 0.009* | 0.337 (0.146–0.779) | 0.011* | |||
Dominant | CC | 82 (57.3%) | 50 (35.2%) | 1.000 | 1.000 | ||||
CT + TT | 61 (42.7%) | 92 (64.8%) | 0.404 (0.251–0.652) | < 0.001** | 0.406 (0.248–0.664) | < 0.001** | |||
Recessive | CC + CT | 132 (92.3%) | 122 (85.9%) | 1.000 | 1.000 | ||||
TT | 11 (7.7%) | 20 (14.1%) | 0.508 (0.234–1.104) | 0.087 | 0.512 (0.231–1.136) | 0.100 | |||