Table 1 Characteristics of the include studies

Benecke 2001 [8]

Retrospective cohort study

Patients underwent tympanoplasty

ADM (human-derived), n = 20

Autologous temporalis fascia, n = 20

6 months

Graft success rate;

Audiometric tests(ABG)

ADM is a suitable material for TM grafting

Min 2018 [26]

Retrospective cohort study

Patients with tympanic membrane perforation who underwent type I tympanoplasty

ADM (human-derived), n = 26

Autologous tragal perichondrium, n = 27

3 months

Graft success rate;

Operation time;

Postoperative pain;

Audiometric tests(ABG,BC)

Tympanoplasty using ADM can be achieved with similar postoperative results and less pain.

Vos 2005 [27]

Retrospective cohort study

Patients underwent type I tympanoplasty without mastoidectomy or ossicular chain reconstruction

ADM (human-derived), n = 25

Autologous temporalis fascia, n = 56;

Autologous fascia plus cartilage reconstruction, n = 33

Not report

Graft success rate;

Audiometric tests(ABG);

Complications

ADM is an effective TM graft when used in type I tympanoplasty

Yang 2019 [28]

Retrospective cohort study

Patients of tympanic membrane perforations who underwent tympanoplasty

ADM (human-derived), n = 27

Autologous tragal perichondrium, n = 34

6 months

Graft success rate;

Operation time;

Audiometric tests(ABG)

ADM can be recommended as an attractive alternative to cartilage grafts

Fu 2017 [29]

Retrospective cohort study

Chronic suppurative otitis media patients underwent type I tympanoplasty

ADM (human-derived), n = 32

Autologous temporalis fascia, n = 28

3 months

Graft success rate;

Operation time;

Postoperative pain

Audiometric tests(ABG)

The effect of ADM for repairing tympanic membrane is similar to the temporalis fascia.

Lee 2018 [22]

Prospective randomised controlled study

Patients who underwent type I tympanoplasty for tympanic membrane perforation

ADM (human-derived), n = 27

Autologous tragal perichondrium, n = 33

6 months

Graft success rate;

Operation time;

Postoperative pain;

Audiometric tests(ABG,AC,BC);

Complications

ADM was shown to be an effective alternative to tragal perichondrium.

Li 2014 [23]

Randomised controlled study

Middle ear cholesteatoma patients underwent tympanoplasty for tympanic membrane perforation

ADM (human-derived), n = 30

Autologous temporalis fascia, n = 22

12 months

Graft success rate;

Audiometric tests(ABG)

ADM was shown to be an effective alternative to the temporalis fascia

Raj 2011 [24]

Prospective randomized unblinded controlled trial

chronic suppurative otitis media patients underwent type I tympanoplasty

ADM (human-derived), n = 20

Autologous temporalis fascia, n = 20

3 months

Graft success rate;

Operation time;

Postoperative pain;

Audiometric tests(ABG,BC)

ADM as graft material are comparable to temporalis fascia in terms of graft uptake and hearing improvement.

Liao 2017 [25]

Randomised controlled study

Chronic suppurative otitis media patients undergoing tympanoplasty

ADM (human-derived), n = 18

Tragus cartilage-perichondrium, n = 69;

Mastoid process periosteum, n = 21;

Temporalis fascia, n = 28

24 months

Graft success rate;

Operation time;

Audiometric tests(ABG)

ADM is suitable for small and medium-sized perforation.