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Table 1 Characteristics of the include studies

From: Human-derived acellular dermal matrix may be an alternative to autologous grafts in tympanic membrane reconstruction: systematic review and meta-analysis

Study Design Participants Interventions Follow-up Outcomes Primary Results
Experimental Control
Benecke 2001 [8] Retrospective cohort study Patients underwent tympanoplasty ADM (human-derived), n = 20 Autologous temporalis fascia, n = 20 6 months Graft success rate;
Audiometric tests(ABG)
ADM is a suitable material for TM grafting
Min 2018 [26] Retrospective cohort study Patients with tympanic membrane perforation who underwent type I tympanoplasty ADM (human-derived), n = 26 Autologous tragal perichondrium, n = 27 3 months Graft success rate;
Operation time;
Postoperative pain;
Audiometric tests(ABG,BC)
Tympanoplasty using ADM can be achieved with similar postoperative results and less pain.
Vos 2005 [27] Retrospective cohort study Patients underwent type I tympanoplasty without mastoidectomy or ossicular chain reconstruction ADM (human-derived), n = 25 Autologous temporalis fascia, n = 56;
Autologous fascia plus cartilage reconstruction, n = 33
Not report Graft success rate;
Audiometric tests(ABG);
Complications
ADM is an effective TM graft when used in type I tympanoplasty
Yang 2019 [28] Retrospective cohort study Patients of tympanic membrane perforations who underwent tympanoplasty ADM (human-derived), n = 27 Autologous tragal perichondrium, n = 34 6 months Graft success rate;
Operation time;
Audiometric tests(ABG)
ADM can be recommended as an attractive alternative to cartilage grafts
Fu 2017 [29] Retrospective cohort study Chronic suppurative otitis media patients underwent type I tympanoplasty ADM (human-derived), n = 32 Autologous temporalis fascia, n = 28 3 months Graft success rate;
Operation time;
Postoperative pain
Audiometric tests(ABG)
The effect of ADM for repairing tympanic membrane is similar to the temporalis fascia.
Lee 2018 [22] Prospective randomised controlled study Patients who underwent type I tympanoplasty for tympanic membrane perforation ADM (human-derived), n = 27 Autologous tragal perichondrium, n = 33 6 months Graft success rate;
Operation time;
Postoperative pain;
Audiometric tests(ABG,AC,BC);
Complications
ADM was shown to be an effective alternative to tragal perichondrium.
Li 2014 [23] Randomised controlled study Middle ear cholesteatoma patients underwent tympanoplasty for tympanic membrane perforation ADM (human-derived), n = 30 Autologous temporalis fascia, n = 22 12 months Graft success rate;
Audiometric tests(ABG)
ADM was shown to be an effective alternative to the temporalis fascia
Raj 2011 [24] Prospective randomized unblinded controlled trial chronic suppurative otitis media patients underwent type I tympanoplasty ADM (human-derived), n = 20 Autologous temporalis fascia, n = 20 3 months Graft success rate;
Operation time;
Postoperative pain;
Audiometric tests(ABG,BC)
ADM as graft material are comparable to temporalis fascia in terms of graft uptake and hearing improvement.
Liao 2017 [25] Randomised controlled study Chronic suppurative otitis media patients undergoing tympanoplasty ADM (human-derived), n = 18 Tragus cartilage-perichondrium, n = 69;
Mastoid process periosteum, n = 21;
Temporalis fascia, n = 28
24 months Graft success rate;
Operation time;
Audiometric tests(ABG)
ADM is suitable for small and medium-sized perforation.
  1. TM Tympanic membrane; ADM Acellular dermal matrix; AC Air conduction BC Bone conduction ABG Air-bone gap