Human-derived acellular dermal matrix may be an alternative to autologous grafts in tympanic membrane reconstruction: systematic review and meta-analysis

Table 2 Characteristics of participants

Study	Country	n	Average age	Causes of TM perforation	Mean perforation size%	ADM derivation	Autologous grafts	Type of surgery	Anesthesia
Benecke 2001 [8]	USA	40	NR	NR	NR	human	Temporalis fascia	Type 1 tympanoplasty	NR
Min 2018 [26]	Korea	53	53.2	NR	22.90%	human	Tragal perichondrium	Type 1 tympanoplasty	Local anesthesia
Vos 2005 [27]	USA	108	20	NR	45%	human	Multiple grafts	Type 1 tympanoplasty	General anesthesia
Yang 2019 [28]	China	61	29.2	NR	NR	human	Tragal perichondrium	Type 1 tympanoplasty	General anesthesia
Fu 2017 [29]	China	60	31.5	Chronic suppurative otitis media	NR	human	Temporalis fascia	Type 1 tympanoplasty	Local anesthesia
Lee 2018 [22]	Korea	60	53.3	NR	NR	human	Tragal perichondrium	Type 1 tympanoplasty	Local anesthesia
Li 2014 [23]	China	52	53	Middle ear cholesteatoma	NR	human	Temporalis fascia	Type 1 tympanoplasty	General anesthesia
Raj 2011 [24]	India	40	NR	Chronic suppurative otitis media	NR	human	Temporalis fascia	Type 1 tympanoplasty	Local anesthesia
Liao 2017 [25]	China	136	41	Chronic suppurative otitis media	NR	human	Multiple grafts	Type 1 tympanoplasty	NR

ISSN: 1916-0216