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Table 1 Study demographics, sample size, and primary anatomic locations

From: Prognostic factors of head and neck cutaneous squamous cell carcinoma: a systematic review

Author Population Sample Size Primary Anatomic Location
Andruchow et al. 2006 [13] Australia 322 Head & Neck
Audet et al. 2004 [14] Canada 56 Head & Neck
Brantsch et al. 2008 [5] Germany 615 Lip (26%), ear (13%), other (61%)
Bobin et al. [15] France 35 Ear (12%), temple (12%), scalp (6%), recurrent lesion (6%)
Ch'ng et al. 2008 [16] New Zealand 170 External ear (26.5%), cheek (12.9%), temporofrontal (18.8%), scalp (11.2%), lower lip (10.6%), upper lip (0.59%), nose (3.53%), eyelid (1.18%), neck (2.35%), multiple head and neck (12.4%)
Chua et al. 2002 [17] Australia 52 Head & Neck
Clark et al. 2012 [9] Australia 603 Head & Neck
Creighton et al. 2018 [18] US 62 Head & Neck
de Koning et al. 2009 [19] Netherlands 99 Oral cavity and oropharynx
Ebrahimi et al. 2013 [20] Australia 229 Face (55.4%), external ear (20.1%), scalp (17.1%), neck (5.7%), other H&N (1.7%)
Eigentler et al. 2017 [21] Germany 1434 Ear (14.4%), Lip (lower vermilion surface) (6.4%), Other (79.2%), Face, other (65.6%), Body, other (13.7%)
Forest et al. 2010 [22] Australia 215 Head & Neck
Garcia-Pedrero et al. [23] Chile 100 Head & Neck
Goh et al. 2012 [24] Australia 66 Head & Neck
Haisma et al. 2016 [25] Netherlands 336 Anterior aspect of the scalp (19.3%), posterior aspect of the scalp (10.8%), neck (4.25), nose (10.5%), lip (16.7%), ear (22.2%), other (16.3%)
Harris et al. 2017 [26] US 212 Ear (22.65), cheek/temple (28.3%), lip (10.4%), neck (2.4%), nose (9.4%), periorbital (5.7%), scalp (15.6%)
Hinerman et al. 2008 [27] US 117 Head & Neck
Hirshoren et al. 2017 [28] Australia 149 Scalp (35%), preauricular (5%), ears (21%), nose (21%), lip lower/upper (11%), neck (1.8%), cheeks (9%), eye lids (0.9%), postauricular (95), chest (0.9%)
Jambusaria-Pahlajani et al. 2013 [29] US 237 Lip or ear (58%), other (42%)
Kelder et al. 2012 [30] Australia 164 Head & Neck
Khandelwal et al. 2016 [31] US 37 Facial
Khurana et al. 1995 [32] Australia 75 Head & Neck
Kreppel et al. 2013 [33] Germany 63 Lower lip (34.9%), upper lip (1.6%), preauricular region (12.7%), nose (12.7%), ear (11.1%), front (4.8%), neurocranium (3.2%), cheek (19.0%)
Kyrgidis et al. 2010 [34] Greece 315 Forehead and temple (17.5%), eyelids and periocular skin (13.0%), auricle and periauricular skin (23.8%), cheek (32.7%), nasal area (8.89%), neck (4.13%)
Makki et al. 2013 [35] Canada 54 Head & Neck
McLean et al. 2013 [36] Australia 100 Head & Neck
Mizrachi et al. 2013 [37] Israel 71 Auricle (19.7%), cheek (16.9%), scalp (11.3%), preauricular region (9.86%), forehead (8.45%), temple (5.63%), chin (4.23%), eyelid (4.23%), neck (4.23%), lip (4.23%), nose (2.82%), other (8.42%)
Moore et al. 2005 [38] US 193 Periauricular (30.6%), forehead/temple (20.2%), cheek (14.0%), nose (9.85%), scalp (8.29%), neck (6.22%), lower lip (4.66%), periorbital (5.2%), upper lip (2.07%)
O’Brien et al., 2002 [3] Australia 87 Head & Neck
Oddone et al. 2009 [39] Australia 250 Head & Neck
Palme et al. 2003 [40] Australia 126 Head & Neck
Peat et al. 2012 [41] New Zealand 170 Head & Neck
Pramana et al. 2012 [42] Australia 75 Scalp (18.7%), ear (16.0%), face (8.0%), neck (2.67%), unknown (54.7%)
Schmidt et al. 2015 [43] Australia 113 Head & Neck
Dyall-Smith et al. 2016 [45] Australia 442 Head & Neck
Sweeny et al. 2014 [44] US 238 Cheek (44%), orbit (2%), forehead (2%), preauricular (115), pinna (20%), postauricular (7%), temporal (6%), unknown (65)
Vasan et al. 2018 [46] Australia 326 Skin of face (19%), external ear (12%), skin of nose (17%), skin of scalp and neck (10%), skin of lip (35), eyelid (< 1%), unknown (28%)
Veness et al. 2005 [6] Australia 167 Head & Neck
Tseros et al. 2016 [47] Australia 238 Head & Neck
Wang et al. 2012 [48] Australia 122 Lip (27%), posterior scalp (9%), cheek (9%), nose (9%), ear (9%), other (37%)