Table 2 Aggressive tumour features
From: BRAF V600E mutation is associated with aggressive features in papillary thyroid carcinomas ≤ 1.5 cm
PTMC (≤ 1 cm) | Small PTC (1.1–1.5 cm) | |||
|---|---|---|---|---|
BRAF | V600E (n = 24) | wt (n = 31) | V600E (n = 28) | wt (n = 38) |
ETE | 4 (16.7%) | 1 (3.2%) | 4 (14.3%) | 1 (2.6%) |
LNM | 10 (41.7%) | 5 (16.1%) | 16 (57.1%)* | 7 (18.4%) |
High-risk variants | ||||
Tall cell | 4 (17.4%)* | 0 | 11 (39.3%)* | 2 (5.3%) |
Columnar | 0 | 0 | 0 | 0 |
Hobnail/Micropapillary | 0 | 0 | 2 (7.1%) | 0 |
Solid/Trabecular | 0 | 0 | 0 | 1 (2.6%) |
Diffuse sclerosing | 0 | 0 | 0 | 1 (2.6%) |
> 1 aggressive feature | 5 (20.8%)* | 0 | 8 (28.6%)* | 1 (2.6%) |
Total Aggressive | 13 (54.2%)* | 6 (19.4%) | 23 (82.1%)* | 11 (28.9%) |