Table 1 Demographics and comorbidities grouped by subglottic stenosis subtype (total sample included 250 patients of all etiologies). Idiopathic patients showed similar features to iatrogenic and autoimmune patients, though some differences were observed among rheumatologic, lung, and liver diseases

Demographics

Number, n (%)

201 (80.4%)

19 (7.6%)

25 (10%)

Age, years (mean ± SD)

54.6 ± 13.48

53.8 ± 21.93

49.3 ± 16.8

Age at diagnosis, years (mean ± SD)

47.8 ± 13.3

48.8 ± 22.9

43.0 ± 16.3

Sex, n (% female)

192 (95%)

17 (89%)

17 (68%)

Comorbidities

Number of comorbidities (mean ± SD)

1.60 ± 1.35

3.37 ± 2.11

3.04 ± 2.35

Charlson comorbidity index (mean ± SD)

0.25 ± 0.86

0.79 ± 1.03

1.04 ± 0.54

Age-adjusted Charlson comorbidity index,

(mean ± SD)

1.44 ± 1.62

2.21 ± 2.10

1.96 ± 1.46

Gastrointestinal

 Gastroesophageal reflux disease, n (%)

65 (32%)

6 (32%)

9 (36%)

 Peptic ulcer disease, n (%)

0

1 (5%)

1 (4%)

 Inflammatory bowel diseases, n (%)

16 (8%)

3 (16%)

1 (4%)

 Liver disease, n (%)

0

2 (11%)

1 (4%)

Metabolic/endocrine

 Hypothyroidism, n (%)

25 (12%)

2 (11%)

2 (8%)

 Diabetes, n (%)

15 (7%)

5 (26%)

1 (4%)

 Dyslipidemia, n (%)

18 (9%)

2 (11%)

2 (8%)

Cardiac

 Hypertension, n (%)

42 (21%)

8 (42%)

6 (24%)

 Myocardial infarction, n (%)

4 (2%)

1 (5%)

0

 Coronary artery disease, n (%)

2 (1%)

1 (5%)

0

 Congestive heart failure, n (%)

2 (1%)

1 (5%)

0

 Stroke, n (%)

2(1%)

0

0

Neurologic/psychiatric

 Fibromyalgia, n (%)

6 (3%)

1 (5%)

3 (12%)

 Migraines, n (%)

5

5

0

 Other psychiatric illnesses, n (%)

10

32

12

Autoimmune/rheumatologic

 Granulomatosis with polyangiitis, n (%)

0

0

14 (56%)

 Rheumatoid arthritis, n (%)

0

1 (5%)

7 (28%)

 Other connective tissue disorders, n (%)

0

0

3 (12%)

Respiratory

 Chronic obstructive pulmonary disease, n (%)

2 (1%)

2 (11%)

0

 Asthma, n (%)

9 (4%)

5 (26%)

3 (12%)

Renal

 Chronic kidney disease, n (%)

3 (2%)

0

0