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Table 2. Association of for single nucleotide polymorphisms (SNPs) of IL1R gene and sudden sensorineural hearing loss (SSNHL) in overall study subjects

From: The association of genetic polymorphisms in interleukin-1 receptors type 1 and type 2 with sudden sensorineural hearing loss in a Taiwanese population: a case control study

SNP

Overall, n (%)

SSNHL case

Control

P valuea

Adjusted OR(95%CI)b, P valuea

rs3917225

    

 Genotypes

    

  AA

154 (38)

270 (37)

P = 0.5845

1.00c

  AG

179 (45)

348 (48)

 

0.875 (0.56–1.37), P = 0.556

  GG

68 (17)

112 (15)

 

0.681 (0.36–1.25), P = 0.219

 Alleles

    

  A

487 (61)

888 (61)

P = 0.9633

1.003

  G

315 (39)

572 (39)

 

0.833 (0.62–1.12), P = 0.229

rs2234650

    

 Genotypes

    

  CC

197 (49)

395 (54)

P = 0.0031*

1.00c

  CT

161 (40)

296 (41)

 

1.273 (0.83–1.96), P = 0.269

  TT

43 (11)

39 (5)

 

2.988 (1.27–6.82), P = 0.012*

 Alleles

    

  C

555 (69)

1086 (74)

P = 0.0083*

1.00c

  T

247 (31)

374 (26)

 

1.448 (1.05–2.00), P = 0.026*

rs4141134

    

 Genotypes

    

  TT

318 (79)

679 (93)

P < 0.0001*

1.00c

  CT

82 (20)

51 (7)

 

3.860 (2.01–7.44), P < 0.0001*

  CC

1 (1)

0 (0)

 

N/A

 Alleles

    

  T

718 (90)

1409 (97)

P < 0.0001*

1.00c

  C

84 (10)

51 (3)

 

3.990 (2.15–7.38), P < 0.0001*

rs2071008

    

 Genotypes

    

  GG

230 (57)

439 (60)

P = 0.3621

1.00c

  GT

145 (36)

257 (35)

 

1.147 (0.74–1.77), P = 0.535

  TT

26 (7)

34 (5)

 

2.233 (0.96–5.07), P = 0.063

  Alleles

    

  G

605 (75)

1135 (78)

P = 0.2136

1.00c

  T

197 (25)

325 (22)

 

1.316 (0.94–1.83), P = 0.107

  1. aChi-squared test
  2. bAdjusted for age, sex (male; female)
  3. cReference group
  4. *p < 0.05
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Journal of Otolaryngology - Head & Neck Surgery

ISSN: 1916-0216

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